One-pot Synthesis, Biological Evaluation and Molecular Docking Studies of Fused Thiazolo[2,3-b]pyrimidinone-pyrazolylcoumarin Hybrids

Overview

Journal Mol Divers

Date 2018 Jul 4

PMID 29968120

Citations 3

Authors

Ramesh Gondru

Saikiran Reddy Peddi

Vijjulatha Manga

Manjulatha Khanapur

Rajitha Gali

Narsimha Sirassu

Rajitha Bavantula

Affiliations

Soon will be listed here.

Abstract

As a part of our endeavor toward the synthesis of a new class of biologically potent heterocyclic hybrids, a series of newly fused thiazolo[2,3-b]pyrimidinones bearing a pyrazolylcoumarin moiety (6a-p) were synthesized in acceptable yields. Anticipated structures of all titled compounds were in agreement with spectral and analytical (C, H and N) analyses. The compounds were screened for in vitro antibacterial activity against both G and G bacterial strains and antiproliferative activity against K562 (chronic myelogenous leukemia), MCF-7 (breast cancer), MDA-MB-231 (breast cancer), COLO 205 (colorectal adenocarcinoma), HepG2 (hepatocellular carcinoma) cell lines. Further, potent antibacterial compounds were subjected to molecular docking studies in order to gain insight into their plausible binding modes and mechanism of action against MurB. The modeling results were in agreement with the experimental data.

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