Type 2 Diabetes is Associated with Higher Trabecular Bone Density but Lower Cortical Bone Density: the Vietnam Osteoporosis Study

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2018 Jul 4

PMID 29967929

Citations 16

Authors

L T Ho-Pham

P M N Chau

A T Do

H C Nguyen

T V Nguyen

Affiliations

Soon will be listed here.

Abstract

Introduction: To define the association between type 2 diabetes and bone architecture and measures of bone strength.

Methods: The study was part of the Vietnam Osteoporosis Study, in which 1115 women and 614 men aged ≥ 30 were randomly recruited from Ho Chi Minh City. HbA levels were measured with analyzers ADAMS™ A HA-8160 (Arkray, Kyoto, Japan). The diagnosis of T2D was made if HbA1c was ≥ 6.5%. Trabecular and cortical volumetric bone density (vBMD) was measured in the forearm and leg by a pQCT XCT2000 (Stratec, Germany). Polar stress strain index (pSSI) was derived from the pQCT measurements. Difference in bone parameters between T2D and non-diabetic individuals was assessed by the number of standard deviations (effect size [ES]) by the propensity score analysis.

Results: The prevalence of T2D was ~ 8%. The results of propensity score matching for age, sex, and body mass index in 137 pairs of diabetic and non-diabetic individuals showed that T2D patients had significantly higher distal radius trabecular vBMD (ES 0.26; 95% CI, 0.02 to 0.50), but lower cortical vBMD (ES - 0.22; - 0.46 to 0.00) and reduced pSSI (ES - 0.23; - 0.47 to - 0.02) compared with non-diabetic individuals. Multiple linear regression analysis based on the entire sample confirmed the results of the propensity score analysis.

Conclusion: Compared with non-diabetic individuals, patients with T2D have greater trabecular but lower cortical vBMD which leads to lower bone strength.

Citing Articles

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