Occupational Exposure to Pesticides in Tobacco Fields: The Integrated Evaluation of Nutritional Intake and Susceptibility on Genomic and Epigenetic Instability

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2018 Jul 4

PMID 29967663

Citations 8

Authors

Vivian F Silva Kahl

Varinderpal Dhillon

Michael Fenech

Melissa Rosa de Souza

Fabiane Nitzke da Silva

Norma Anair Possa Marroni

Emilene Arusievicz Nunes

Giselle Cerchiaro

Tatiana Pedron

Bruno Lemos Batista

Monica Cappetta

Wilner Martinez-Lopez

Daniel Simon

Juliana da Silva

Affiliations

Soon will be listed here.

Abstract

Pesticides used at tobacco fields are associated with genomic instability, which is proposed to be sensitive to nutritional intake and may also induce epigenetic changes. We evaluated the effect of dietary intake and genetic susceptibility polymorphisms in (rs1801133) and (rs2736100) genes on genomic and epigenetic instability in tobacco farmers. Farmers, when compared to a nonexposed group, showed increased levels of different parameters of DNA damage (micronuclei, nucleoplasmic bridges, and nuclear buds), evaluated by cytokinesis-block micronucleus cytome assay. Telomere length (TL) measured by quantitative PCR was shorter in exposed individuals. Global DNA methylation was significantly decreased in tobacco farmers. The exposed group had lower dietary intake of fiber, but an increase in cholesterol; vitamins such as B, B, and C; -carotene; and -retinol. Several trace and ultratrace elements were found higher in farmers than in nonfarmers. The genotype influenced nucleoplasmic bridges, nuclear buds, and TL in the exposed group, whereas only affected micronucleus frequency. We observed a positive correlation of TL and lipids and an inverse correlation of TL and fibers. The present data suggest an important role of dietary intake and subjects' genetic susceptibility to xenobiotics-induced damages and epigenetic alterations in tobacco farmers occupationally exposed to mixtures of pesticides.

Citing Articles

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A few-shot learning method for tobacco abnormality identification.

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Jimenez-Garza O, Ghosh M, Barrow T, Godderis L Front Public Health. 2023; 11:1073658.

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Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review.

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