In Vitro and In Vivo Experimental Studies of PM on Disease Progression

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2018 Jul 4

PMID 29966381

Citations 50

Authors

Ching-Chang Cho

Wen-Yeh Hsieh

Chin-Hung Tsai

Cheng-Yi Chen

Hui-Fang Chang

Chih-Sheng Lin

Affiliations

Soon will be listed here.

Abstract

Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM), and the components may also have different effects on people. The pathogenesis of PM in several diseases remains to be clarified. There is a long history of epidemiological research on PM in several diseases. Numerous studies show that PM can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM-induced disease.

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