Breast Cancer Recurrence After Reconstruction: Know Thine Enemy

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 Jul 3

PMID 29963246

Citations 8

Authors

Elizabeth A Brett

Matthias M Aitzetmuller

Matthias A Sauter

Georg M Huemer

Hans-Gunther Machens

Dominik Duscher

Affiliations

Soon will be listed here.

Abstract

Breast reconstruction proceeding cancer treatment carries risk, regardless of the type of surgery. From fat grafting, to flap placement, to implants, there is no guarantee that reconstruction will not stimulate breast cancer recurrence. Research in this field is clearly divided into two parts: scientific interventional studies and clinical retrospective evidence. The reconstructive procedure offers hypoxia, a wound microenvironment, bacterial load, adipose derived stem cells; agents shown experimentally to cause increased cancer cell activity. This is compelling scientific evidence which serves to bring uncertainty and fear to the reconstructive procedure. In the absence of clinical evidence, this laboratory literature landscape is now informing surgical choices. Curiously, clinical studies have not shown a clear link between breast cancer recurrence and reconstructive surgery. Where does that leave us? This review aims to analyze the science and the surgery, thereby understanding the oncological fear which accompanies breast cancer reconstruction.

Citing Articles

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Comparison of outcomes between immediate implantbased and autologous reconstruction: 15-year, single-center experience in a propensity score-matched Chinese cohort.

He S, Ding B, Li G, Huang Y, Han C, Sun J Cancer Biol Med. 2021; 19(9).

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