Breast Abscess Caused by in 2 Adolescent Girls with Atopic Dermatitis

Overview

Journal Korean J Pediatr

Specialty Pediatrics

Date 2018 Jul 3

PMID 29963104

Citations 3

Authors

Sung Man Park

Won Sik Choi

Yoonsun Yoon

Gee Hae Jung

Chang Kyu Lee

So Hyun Ahn

Yoon Wonsuck

Young Yoo

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease in children. Patients with AD experience a high rate of colonization of the skin surface by . Because of a skin barrier defect, there is a potential risk of staphylococcal invasive infection in patients with AD. Here, we present 2 cases of breast abscess caused by in 2 adolescent girls with severe AD. Methicillin-sensitive was identified from the breast abscess material. They were treated with appropriate antibiotics, however surgical drainage of the abscess was needed in case 1. Identical strains were found from the breast abscess material as well as the lesional and the nonlesional skin of the patients through matrixassisted laser desorption/ionization time-of-flight analysis. We characterized the differential abundance of Firmicutes phylum in patients' skin in microbiota analysis. In particular, , a member of Firmicutes, differed significantly between the lesional and the normal-appearing skin. Our cases demonstrate the potential severity of bacterial deep tissue infection in AD and the dysbiosis of skin microbiota may be involved in inflammation in AD.

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References

Williams M, Gallo R . The role of the skin microbiome in atopic dermatitis. Curr Allergy Asthma Rep. 2015; 15(11):65. DOI: 10.1007/s11882-015-0567-4. View

Ong P, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T . Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002; 347(15):1151-60. DOI: 10.1056/NEJMoa021481. View

Boguniewicz M, Leung D . Atopic dermatitis: a disease of altered skin barrier and immune dysregulation. Immunol Rev. 2011; 242(1):233-46. PMC: 3122139. DOI: 10.1111/j.1600-065X.2011.01027.x. View

Gollapalli V, Liao J, Dudakovic A, Sugg S, Scott-Conner C, Weigel R . Risk factors for development and recurrence of primary breast abscesses. J Am Coll Surg. 2010; 211(1):41-8. DOI: 10.1016/j.jamcollsurg.2010.04.007. View

Hoeger P, Ganschow R, Finger G . Staphylococcal septicemia in children with atopic dermatitis. Pediatr Dermatol. 2000; 17(2):111-4. DOI: 10.1046/j.1525-1470.2000.01725.x. View

Kong H, Oh J, Deming C, Conlan S, Grice E, Beatson M . Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res. 2012; 22(5):850-9. PMC: 3337431. DOI: 10.1101/gr.131029.111. View

Huang J, Abrams M, Tlougan B, Rademaker A, Paller A . Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics. 2009; 123(5):e808-14. DOI: 10.1542/peds.2008-2217. View

Gonzalez M, Schaffer J, Orlow S, Gao Z, Li H, Alekseyenko A . Cutaneous microbiome effects of fluticasone propionate cream and adjunctive bleach baths in childhood atopic dermatitis. J Am Acad Dermatol. 2016; 75(3):481-493.e8. PMC: 4992571. DOI: 10.1016/j.jaad.2016.04.066. View

Benenson S, Zimhony O, Dahan D, Solomon M, Raveh D, Schlesinger Y . Atopic dermatitis--a risk factor for invasive Staphylococcus aureus infections: two cases and review. Am J Med. 2005; 118(9):1048-51. DOI: 10.1016/j.amjmed.2005.03.040. View

10.

Bunikowski R, Mielke M, Skarabis H, Worm M, Anagnostopoulos I, Kolde G . Evidence for a disease-promoting effect of Staphylococcus aureus-derived exotoxins in atopic dermatitis. J Allergy Clin Immunol. 2000; 105(4):814-9. DOI: 10.1067/mai.2000.105528. View

11.

Tauber M, Balica S, Hsu C, Jean-Decoster C, Lauze C, Redoules D . Staphylococcus aureus density on lesional and nonlesional skin is strongly associated with disease severity in atopic dermatitis. J Allergy Clin Immunol. 2015; 137(4):1272-1274.e3. DOI: 10.1016/j.jaci.2015.07.052. View

12.

Seite S, Flores G, Henley J, Martin R, Zelenkova H, Aguilar L . Microbiome of affected and unaffected skin of patients with atopic dermatitis before and after emollient treatment. J Drugs Dermatol. 2015; 13(11):1365-72. View

13.

Horimoto K, Kubo T, Matsusaka H, Baba H, Umesue M . Right-sided infective endocarditis with a ruptured sinus of Valsalva and multiple septic pulmonary emboli in a patient with atopic dermatitis. Intern Med. 2015; 54(7):797-800. DOI: 10.2169/internalmedicine.54.3374. View

14.

Faden H . Mastitis in children from birth to 17 years. Pediatr Infect Dis J. 2005; 24(12):1113. DOI: 10.1097/01.inf.0000190031.59905.9f. View

15.

Kitamura S, Nakayama Y, Shirai Y, Hashiguchi H, Kim R . Septic arthritis of the hip associated with atopic dermatitis. A case report. J Nippon Med Sch. 2000; 67(6):464-7. DOI: 10.1272/jnms.67.464. View

16.

Mohiyiddeen G, Brett I, Jude E . Infective endocarditis caused by Staphylococcus aureus in a patient with atopic dermatitis: a case report. J Med Case Rep. 2008; 2:143. PMC: 2390575. DOI: 10.1186/1752-1947-2-143. View