MicroRNA-Related Polymorphisms in Infectious Diseases-Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2018 Jul 3

PMID 29963045

Citations 13

Authors

Joel Henrique Ellwanger

Francis Maria Bao Zambra

Rafael Lima Guimaraes

Jose Artur Bogo Chies

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are single-stranded sequences of non-coding RNA with approximately 22 nucleotides that act posttranscriptionally on gene expression. miRNAs are important gene regulators in physiological contexts, but they also impact the pathogenesis of various diseases. The role of miRNAs in viral infections has been explored by different authors in both population-based as well as in functional studies. However, the effect of miRNA polymorphisms on the susceptibility to viral infections and on the clinical course of these diseases is still an emerging topic. Thus, this review will compile and organize the findings described in studies that evaluated the effects of genetic variations on miRNA genes and on their binding sites, in the context of human viral diseases. In addition to discussing the basic aspects of miRNAs biology, we will cover the studies that investigated miRNA polymorphisms in infections caused by hepatitis B virus, hepatitis C virus, human immunodeficiency virus, Epstein-Barr virus, and human papillomavirus. Finally, emerging topics concerning the importance of miRNA genetic variants will be presented, focusing on the context of viral infectious diseases.

Citing Articles

Association between SNPs in microRNAs and microRNAs-Machinery Genes with Susceptibility of Leprosy in the Amazon Population.

da Silva M, Leal D, Sena C, Pinto P, Gobbo A, da Silva M Int J Mol Sci. 2022; 23(18).

PMID: 36142557 PMC: 9503809. DOI: 10.3390/ijms231810628.

Differential impact of the angiotensin-converting enzyme-2 (ACE2 rs4343 G>A) and miR-196a2 rs11614913 C>T gene alterations in COVID-19 disease severity and mortality.

Mir M, Mir R, Alghamdi M, Alsayed B, Elfaki I, Al Bshabshe A Exp Ther Med. 2022; 23(6):418.

PMID: 35601073 PMC: 9117950. DOI: 10.3892/etm.2022.11345.

Association of toll-like receptors single nucleotide polymorphisms with HBV and HCV infection: research status.

Xu Y, Xue W, Gao H, Cui J, Zhao L, You C PeerJ. 2022; 10:e13335.

PMID: 35462764 PMC: 9029363. DOI: 10.7717/peerj.13335.

Clinical Implications of Krüpple-like Transcription Factor KLF-14 and Certain Micro-RNA (miR-27a, miR-196a2, miR-423) Gene Variations as a Risk Factor in the Genetic Predisposition to PCOS.

Mir R, Saeedi N, Jalal M, Altayar M, Barnawi J, Hamadi A J Pers Med. 2022; 12(4).

PMID: 35455702 PMC: 9030665. DOI: 10.3390/jpm12040586.

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population.

Kulmann-Leal B, Ellwanger J, Chies J Front Immunol. 2021; 12:758358.

PMID: 34956188 PMC: 8703165. DOI: 10.3389/fimmu.2021.758358.

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