Is Essential for Development and Virulence in Chestnut Blight Fungus

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2018 Jul 3

PMID 29963030

Citations 10

Authors

Qi Chen

Yongbing Li

Jinzi Wang

Ru Li

Baoshan Chen

Affiliations

Soon will be listed here.

Abstract

Ubiquitination plays key roles in eukaryotic growth, stress adaptation, and metabolic regulation. In our previous work, ubiquitin was found to be secreted in the hypovirus-infected strain of , a phytopathogenic filamentous fungus responsible for the chestnut blight. Here we report the functional and molecular characterization of a polyubiquitin gene, , in . The expression of was upregulated by the infection of a hypovirus. Deletion of resulted in abnormal morphology, reduced sporulation, attenuation of virulence, and significant reduction in ubiquitination. A total of 378 sites in 236 proteins were identified to be significantly decreased in ubiquitination in the absence of . Quantitative proteome analysis revealed that 285 in 4,776 identified proteins changed in abundance (1.5-fold, < 0.05) in the null mutant, as compared with the wild-type strain.

Citing Articles

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N6-methyladenosine RNA methyltransferase CpMTA1 mediates CpAphA mRNA stability through a YTHDF1-dependent m6A modification in the chestnut blight fungus.

Zhao L, Wei X, Chen F, Yuan L, Chen B, Li R PLoS Pathog. 2024; 20(8):e1012476.

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