Cousins at Work: How Combining Medical with Optical Imaging Enhances in Vivo Cell Tracking

Overview

Journal Int J Biochem Cell Biol

Publisher Elsevier

Specialties Biochemistry
Cell Biology

Date 2018 Jul 1

PMID 29960079

Citations 23

Authors

Alessia Volpe

Ewelina Kurtys

Gilbert O Fruhwirth

Affiliations

Soon will be listed here.

Abstract

Microscopy and medical imaging are related in their exploitation of electromagnetic waves, but were developed to satisfy differing needs, namely to observe small objects or to look inside subjects/objects, respectively. Together, these techniques can help elucidate complex biological processes and better understand health and disease. A current major challenge is to delineate mechanisms governing cell migration and tissue invasion in organismal development, the immune system and in human diseases such as cancer where the spatiotemporal tracking of small cell numbers in live animal models is extremely challenging. Multi-modal multi-scale in vivo cell tracking integrates medical and optical imaging. Fuelled by basic research in cancer biology and cell-based therapeutics, it has been enabled by technological advances providing enhanced resolution, sensitivity and multiplexing capabilities. Here, we review which imaging modalities have been successfully used for in vivo cell tracking and how this challenging task has benefitted from combining macroscopic with microscopic techniques.

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