Cellular Target Engagement: a New Paradigm in Drug Discovery
Overview
Affiliations
Gao S, Li M, Smith J, Intes X Biomed Opt Express. 2022; 13(9):4637-4651.
PMID: 36187247 PMC: 9484415. DOI: 10.1364/BOE.460216.
Why 90% of clinical drug development fails and how to improve it?.
Sun D, Gao W, Hu H, Zhou S Acta Pharm Sin B. 2022; 12(7):3049-3062.
PMID: 35865092 PMC: 9293739. DOI: 10.1016/j.apsb.2022.02.002.
Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety.
Gao W, Hu H, Dai L, He M, Yuan H, Zhang H Acta Pharm Sin B. 2022; 12(5):2462-2478.
PMID: 35646532 PMC: 9136610. DOI: 10.1016/j.apsb.2022.02.015.
Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis.
Kim M, Gernapudi R, Cedeno Y, Polster B, Martinez R, Shapiro P Oncotarget. 2020; 11(43):3863-3885.
PMID: 33196708 PMC: 7597410. DOI: 10.18632/oncotarget.27743.
Baxter M, Chapagai D, Craig S, Hurtado C, Varghese J, Nurmemmedov E ChemMedChem. 2020; 15(12):1058-1066.
PMID: 32232973 PMC: 7703809. DOI: 10.1002/cmdc.202000137.