A Case Report of Guardian-consent Forced Paliperidone Palmitate for Behavioral Disturbance Due to Traumatic Brain Injury

Overview

Journal Ment Health Clin

Specialty Psychiatry

Date 2018 Jun 30

PMID 29955561

Authors

Amber R Douglass

Uyen Smyth

Affiliations

Soon will be listed here.

Abstract

Psychosis after traumatic brain injury (TBI) occurs in up to 10% of cases. Although guideline consensus is lacking regarding drugs of choice for this condition, current literature points to the use of atypical antipsychotics. This case describes a 58-year-old male with major neurocognitive disorder due to TBI with behavioral disturbance that was successfully treated with paliperidone palmitate. In addition to the off-label use of paliperidone, this case also explores the use of forced medication as the initial injection was given per guardian consent. After completion of a literature review, this appears to be the first case report describing the use of a long-acting antipsychotic for the treatment of TBI-related psychosis. This case suggests that paliperidone palmitate may be efficacious for psychosis following TBI; however, further study is warranted.

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