Cocoa Pod Husk Pectin Intended As a Pharmaceutical Excipient Has No Adverse Effects on Haematological Parameters in Sprague Dawley Rats

Overview

Journal J Pharm (Cairo)

Specialty Pharmacology

Date 2018 Jun 30

PMID 29955438

Citations 4

Authors

Ofosua Adi-Dako

Kwabena Ofori-Kwakye

Kennedy Kwami Edem Kukuia

Jerry Asiedu-Larbi

Alexander Kwadwo Nyarko

Doris Kumadoh

Grace Frimpong

Affiliations

Soon will be listed here.

Abstract

Natural polymer research has recently become the focus of intensive research in the quest for new enabling excipients for novel drugs in pharmaceutical formulation for optimal treatment outcomes. Evaluations of some excipients have shown deleterious haematological effects of varying extents on the safety profile of these excipients. A 90-day subchronic toxicity study was conducted to evaluate the influence of cocoa pod husk (CPH) pectin on indicators for haematotoxicity. Male and female Sprague Dawley rats (SDRs) were fed with CPH pectin in doses up to 71.4 mg/kg. The effects of CPH pectin on the haematological indices, direct and total bilirubin, and the spleen were determined. The results indicated that CPH pectin did not induce any untoward toxic effects on the haematological indices, bilirubin levels, and the spleen. There were, however, elevations in MCV at day 30, which was not sustained after the 90 days. The data obtained from this study did not reveal any remarkable findings of toxicological relevance to the haematopoietic system.

Citing Articles

Cocoa by-products: A comprehensive review on potential uses, waste management, and emerging green technologies for cocoa pod husk utilization.

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Pharmaceutical and pharmacokinetic evaluation of a newly formulated multiparticulate matrix of levodopa and carbidopa.

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A review on anti-peptic ulcer activities of medicinal plants used in the formulation of and .

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Identification of potential maturity indicators for harvesting cacao.

Rojas K, Garcia M, Ceron I, Ortiz R, Tarazona M Heliyon. 2020; 6(2):e03416.

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