Multifunctional Electrospun Nanofibers for Enhancing Localized Cancer Treatment

Overview

Journal Small

Date 2018 Jun 29

PMID 29952070

Citations 15

Authors

Yike Fu

Xiang Li

Zhaohui Ren

Chuanbin Mao

Gaorong Han

Affiliations

Soon will be listed here.

Abstract

Localized cancer treatment is one of the most effective strategies in clinical destruction of solid tumors at early stages as it can minimize the side effects of cancer therapeutics. Electrospun nanofibers have been demonstrated as a promising implantable platform in localized cancer treatment, enabling the on-site delivery of therapeutic components and minimizing side effects to normal tissues. This Review discusses the recent cutting-edge research with regard to electrospun nanofibers used for various therapeutic approaches, including gene therapy, chemotherapy, photodynamic therapy, thermal therapy, and combination therapy, in enhancing localized cancer treatment. Furthermore, it extensively analyzes the current challenges and potential breakthroughs in utilizing this novel platform for clinical transition in localized cancer treatment.

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References

Yan L, Chang Y, Yin W, Tian G, Zhou L, Liu X . On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells. Biomater Sci. 2020; 2(10):1412-1418. DOI: 10.1039/c4bm00143e. View

Redmond R, Kochevar I . Spatially resolved cellular responses to singlet oxygen. Photochem Photobiol. 2006; 82(5):1178-86. DOI: 10.1562/2006-04-14-IR-874. View

Zhang Z, Wang J, Chen C . Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv Mater. 2013; 25(28):3869-80. DOI: 10.1002/adma.201301890. View

Yuan Z, Wu W, Zhang Z, Sun Z, Cheng R, Pan G . In situ adjuvant therapy using a responsive doxorubicin-loaded fibrous scaffold after tumor resection. Colloids Surf B Biointerfaces. 2017; 158:363-369. DOI: 10.1016/j.colsurfb.2017.06.052. View

Fisher J, Sarkar S, Buchanan C, Szot C, Whitney J, Hatcher H . Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation. Cancer Res. 2010; 70(23):9855-64. PMC: 3699181. DOI: 10.1158/0008-5472.CAN-10-0250. View

Li T, Huang C, Ruan P, Chuang K, Huang K, Shieh D . In vivo anti-cancer efficacy of magnetite nanocrystal--based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy. Biomaterials. 2013; 34(32):7873-83. DOI: 10.1016/j.biomaterials.2013.07.012. View

Li L, Yang G, Zhou G, Wang Y, Zheng X, Zhou S . Thermally Switched Release from a Nanogel-in-Microfiber Device. Adv Healthc Mater. 2015; 4(11):1658-63. DOI: 10.1002/adhm.201500267. View

Wang S, Shang L, Li L, Yu Y, Chi C, Wang K . Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy. Adv Mater. 2016; 28(38):8379-8387. DOI: 10.1002/adma.201602197. View

Webb B, Chimenti M, Jacobson M, Barber D . Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer. 2011; 11(9):671-7. DOI: 10.1038/nrc3110. View

10.

Lin T, Lin F, Lin J . In vitro feasibility study of the use of a magnetic electrospun chitosan nanofiber composite for hyperthermia treatment of tumor cells. Acta Biomater. 2012; 8(7):2704-11. DOI: 10.1016/j.actbio.2012.03.045. View

11.

Taheri M, Mahjoubi F . MRP1 but not MDR1 is associated with response to neoadjuvant chemotherapy in breast cancer patients. Dis Markers. 2013; 34(6):387-93. PMC: 3809982. DOI: 10.3233/DMA-130985. View

12.

Liu D, Liu S, Jing X, Li X, Li W, Huang Y . Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats. Biomaterials. 2012; 33(17):4362-9. DOI: 10.1016/j.biomaterials.2012.02.062. View

13.

Wang X, Lv F, Li T, Han Y, Yi Z, Liu M . Electrospun Micropatterned Nanocomposites Incorporated with CuS Nanoflowers for Skin Tumor Therapy and Wound Healing. ACS Nano. 2017; 11(11):11337-11349. DOI: 10.1021/acsnano.7b05858. View

14.

Fonseca A, Serra A, Coelho J . Bioabsorbable polymers in cancer therapy: latest developments. EPMA J. 2015; 6:22. PMC: 4657262. DOI: 10.1186/s13167-015-0045-z. View

15.

Gong L, Yan L, Zhou R, Xie J, Wu W, Gu Z . Two-dimensional transition metal dichalcogenide nanomaterials for combination cancer therapy. J Mater Chem B. 2020; 5(10):1873-1895. DOI: 10.1039/c7tb00195a. View

16.

Mauro N, Scialabba C, Pitarresi G, Giammona G . Enhanced adhesion and in situ photothermal ablation of cancer cells in surface-functionalized electrospun microfiber scaffold with graphene oxide. Int J Pharm. 2017; 526(1-2):167-177. DOI: 10.1016/j.ijpharm.2017.04.045. View

17.

Lucky S, Soo K, Zhang Y . Nanoparticles in photodynamic therapy. Chem Rev. 2015; 115(4):1990-2042. DOI: 10.1021/cr5004198. View

18.

Liang C, Xu L, Song G, Liu Z . Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy. Chem Soc Rev. 2016; 45(22):6250-6269. DOI: 10.1039/c6cs00458j. View

19.

Teo P, Cheng W, Hedrick J, Yang Y . Co-delivery of drugs and plasmid DNA for cancer therapy. Adv Drug Deliv Rev. 2015; 98:41-63. DOI: 10.1016/j.addr.2015.10.014. View

20.

Guimaraes P, Oliveira M, Gomes A, Gontijo S, Cortes M, Campos P . PLGA nanofibers improves the antitumoral effect of daunorubicin. Colloids Surf B Biointerfaces. 2015; 136:248-55. DOI: 10.1016/j.colsurfb.2015.09.005. View