Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2018 Jun 29

PMID 29949870

Citations 9

Authors

Danelle Rolle-McFarland

Yingzi Liu

Jieqiong Zhou

Farshad Mostafaei

Yuanzhong Zhou

Yan Li

Quiyan Fan

Wei Zheng

Linda H Nie

Ellen M Wells

Affiliations

Soon will be listed here.

Abstract

Manganese (Mn) exposure can result in parkinsonism. However, understanding of manganese neurotoxicity has been limited by the lack of a cumulative Mn biomarker. Therefore, the current goal was to develop Mn cumulative exposure indices (MnCEI), an established method to estimate cumulative exposure, and determine associations of MnCEI with blood Mn (BMn), fingernail Mn (FMn), and bone Mn (BnMn). We completed a cross-sectional study of 60 male Chinese workers. Self-reported occupational history was used to create two MnCEIs reflecting the previous 16 years (MnCEI) and total work history (MnCEI). An in vivo neutron activation analysis system was used to quantify BnMn. BMn and FMn were measured using ICP-MS. Mean (standard deviation) MnCEI and MnCEI were 37.5 (22.0) and 25.0 (11.3), respectively. Median (interquartile range) BMn, FMn, and BnMn were 14.1 (4.0) μg/L, 13.5 (58.5) μg/g, and 2.6 (7.2) μg/g dry bone, respectively. MnCEI was significantly correlated with FMn (Spearman’s = 0.44; = 0.02), BnMn ( = 0.44; < 0.01), and MnCEI ( = 0.44; < 0.01). In adjusted regression models, MnCEI was significantly associated with BnMn (β = 0.03; 95% confidence interval = 0.001, 0.05); no other biomarkers were associated with MnCEI. This suggests BnMn may be a useful biomarker of the previous 16 years of Mn exposure, but larger studies are recommended.

Citing Articles

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The association of bone and blood manganese with motor function in Chinese workers.

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Bone manganese is a sensitive biomarker of ongoing elevated manganese exposure, but does not accumulate across the lifespan.

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Chronic Manganese Administration with Longer Intervals Between Injections Produced Neurotoxicity and Hepatotoxicity in Rats.

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References

Succop P, Clark S, Chen M, Galke W . Imputation of data values that are less than a detection limit. J Occup Environ Hyg. 2004; 1(7):436-41. DOI: 10.1080/15459620490462797. View

Park S, Mukherjee B, Xia X, Sparrow D, Weisskopf M, Nie H . Bone lead level prediction models and their application to examine the relationship of lead exposure and hypertension in the Third National Health and Nutrition Examination Survey. J Occup Environ Med. 2009; 51(12):1422-36. PMC: 2939477. DOI: 10.1097/JOM.0b013e3181bf6c8d. View

Bouchard M, Mergler D, Baldwin M, Panisset M . Manganese cumulative exposure and symptoms: a follow-up study of alloy workers. Neurotoxicology. 2008; 29(4):577-83. DOI: 10.1016/j.neuro.2008.04.013. View

Ramlow J, Spadacene N, Hoag S, Stafford B, Cartmill J, Lerner P . Mortality in a cohort of pentachlorophenol manufacturing workers, 1940-1989. Am J Ind Med. 1996; 30(2):180-94. DOI: 10.1002/(SICI)1097-0274(199608)30:2<180::AID-AJIM9>3.0.CO;2-4. View

Laohaudomchok W, Lin X, Herrick R, Fang S, Cavallari J, Christiani D . Toenail, blood, and urine as biomarkers of manganese exposure. J Occup Environ Med. 2011; 53(5):506-10. PMC: 3092003. DOI: 10.1097/JOM.0b013e31821854da. View

Zayed J, Mikhail M, Loranger S, Kennedy G, LEsperance G . Exposure of taxi drivers and office workers to total and respirable manganese in an urban environment. Am Ind Hyg Assoc J. 1996; 57(4):376-80. DOI: 10.1080/15428119691014927. View

Racette B, Aschner M, Guilarte T, Dydak U, Criswell S, Zheng W . Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology. 2011; 33(4):881-6. PMC: 3350837. DOI: 10.1016/j.neuro.2011.12.010. View

Apostoli P, Lucchini R, Alessio L . Are current biomarkers suitable for the assessment of manganese exposure in individual workers?. Am J Ind Med. 2000; 37(3):283-90. DOI: 10.1002/(sici)1097-0274(200003)37:3<283::aid-ajim6>3.0.co;2-e. View

ONeal S, Lee J, Zheng W, Cannon J . Subacute manganese exposure in rats is a neurochemical model of early manganese toxicity. Neurotoxicology. 2014; 44:303-13. PMC: 4278355. DOI: 10.1016/j.neuro.2014.08.001. View

10.

Wells E, Liu Y, Rolle-McFarland D, Mostafaei F, Zheng W, Nie L . In vivo measurement of bone manganese and association with manual dexterity: A pilot study. Environ Res. 2017; 160:35-38. PMC: 5962822. DOI: 10.1016/j.envres.2017.09.016. View

11.

Jarvisalo J, Olkinuora M, Kiilunen M, Kivisto H, Ristola P, Tossavainen A . Urinary and blood manganese in occupationally nonexposed populations and in manual metal arc welders of mild steel. Int Arch Occup Environ Health. 1992; 63(7):495-501. DOI: 10.1007/BF00572116. View

12.

Zhang L, Lu L, Pan Y, Ding C, Xu D, Huang C . Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb. Environ Res. 2015; 140:10-7. PMC: 4492836. DOI: 10.1016/j.envres.2015.03.008. View

13.

Grashow R, Zhang J, Fang S, Weisskopf M, Christiani D, Cavallari J . Toenail metal concentration as a biomarker of occupational welding fume exposure. J Occup Environ Hyg. 2013; 11(6):397-405. PMC: 4019688. DOI: 10.1080/15459624.2013.875182. View

14.

Bowler R, Gysens S, Diamond E, Nakagawa S, Drezgic M, Roels H . Manganese exposure: neuropsychological and neurological symptoms and effects in welders. Neurotoxicology. 2005; 27(3):315-26. DOI: 10.1016/j.neuro.2005.10.007. View

15.

Pejovic-Milic A, Chettle D, Oudyk J, Pysklywec M, Haines T . Bone manganese as a biomarker of manganese exposure: a feasibility study. Am J Ind Med. 2009; 52(10):742-50. DOI: 10.1002/ajim.20737. View

16.

Sierra P, Loranger S, Kennedy G, Zayed J . Occupational and environmental exposure of automobile mechanics and nonautomotive workers to airborne manganese arising from the combustion of methylcyclopentadienyl manganese tricarbonyl (MMT). Am Ind Hyg Assoc J. 1995; 56(7):713-6. DOI: 10.1080/15428119591016746. View

17.

Ellingsen D, Dubeikovskaya L, Dahl K, Chashchin M, Chashchin V, Zibarev E . Air exposure assessment and biological monitoring of manganese and other major welding fume components in welders. J Environ Monit. 2007; 8(10):1078-86. DOI: 10.1039/b605549d. View

18.

Fayerweather W, KARNS M, Nuwayhid I, Nelson T . Case-control study of cancer risk in tetraethyl lead manufacturing. Am J Ind Med. 1997; 31(1):28-35. DOI: 10.1002/(sici)1097-0274(199701)31:1<28::aid-ajim5>3.0.co;2-t. View

19.

Eastman R, Jursa T, Benedetti C, Lucchini R, Smith D . Hair as a biomarker of environmental manganese exposure. Environ Sci Technol. 2012; 47(3):1629-37. PMC: 3583582. DOI: 10.1021/es3035297. View

20.

Ferraz H, Bertolucci P, Pereira J, Lima J, Andrade L . Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology. 1988; 38(4):550-3. DOI: 10.1212/wnl.38.4.550. View