Characteristics of the Antibiotic Regimen That Affect Antimicrobial Resistance in Urinary Pathogens

Overview

Journal Antimicrob Resist Infect Control

Publisher Biomed Central

Specialty Infectious Diseases

Date 2018 Jun 28

PMID 29946451

Citations 4

Authors

Boudewijn Catry

Katrien Latour

Robin Bruyndonckx

Camellia Diba

Candida Geerdens

Samuel Coenen

Affiliations

Soon will be listed here.

Abstract

Background: Treatment duration, treatment interval, formulation and type of antimicrobial (antibiotic) are modifiable factors that will influence antimicrobial selection pressure. Currently, the impact of the route of administration on the occurrence of resistance in humans is unclear.

Methods: In this retrospective multi-center cohort study, we assessed the impact of different variables on antimicrobial resistance (AMR) in pathogens isolated from the urinary tract in older adults. A generalized estimating equations (GEE) model was constructed using 7397 () isolates.

Results: Resistance in was higher when more antibiotics had been prescribed before isolation of the sample, especially in women (significant interaction = 0.0016) and up to nine preceding prescriptions it was lower for higher proportions of preceding parenteral prescriptions (significant interactions = 0.0067). The laboratory identity, dying, and the time between prescription and sampling were important confounders ( < 0.001).

Conclusions: Our model describing shows a dose-response relation between antibiotic use and AMR in isolated from urine samples of older adults, and, for the first time, that higher proportions of preceding parenteral prescriptions are significantly associated with lower probabilities of AMR, provided that the number of preceding prescriptions is not extremely high (≥10 during the 1.5 year observation period; 93% of 5650 included patients).

Trial Registration: Retrospectively registered.

Citing Articles

Patients receiving a high burden of antibiotics in the community in Spain: a cross-sectional study.

Fernandez-Urrusuno R, Meseguer Barros C, Anaya-Ordonez S, Borrego Izquierdo Y, Lallana-Alvarez M, Madridejos R Pharmacol Res Perspect. 2020; 9(1):e00692.

PMID: 33340264 PMC: 7749514. DOI: 10.1002/prp2.692.

Resistance Levels and Epidemiology of Non-Fermenting Gram-Negative Bacteria in Urinary Tract Infections of Inpatients and Outpatients (RENFUTI): A 10-Year Epidemiological Snapshot.

Gajdacs M, Burian K, Terhes G Antibiotics (Basel). 2019; 8(3).

PMID: 31505817 PMC: 6784256. DOI: 10.3390/antibiotics8030143.

Comparative Epidemiology and Resistance Trends of in Urinary Tract Infections of Inpatients and Outpatients: A 10-Year Retrospective Study.

Gajdacs M, Urban E Antibiotics (Basel). 2019; 8(3).

PMID: 31373311 PMC: 6783862. DOI: 10.3390/antibiotics8030091.

The distribution of antibiotic use and its association with antibiotic resistance.

Olesen S, Barnett M, MacFadden D, Brownstein J, Hernandez-Diaz S, Lipsitch M Elife. 2018; 7.

PMID: 30560781 PMC: 6307856. DOI: 10.7554/eLife.39435.

References

Lafaurie M, Porcher R, Donay J, Touratier S, Molina J . Reduction of fluoroquinolone use is associated with a decrease in methicillin-resistant Staphylococcus aureus and fluoroquinolone-resistant Pseudomonas aeruginosa isolation rates: a 10 year study. J Antimicrob Chemother. 2012; 67(4):1010-5. DOI: 10.1093/jac/dkr555. View

Dryden M, Johnson A, Ashiru-Oredope D, Sharland M . Using antibiotics responsibly: right drug, right time, right dose, right duration. J Antimicrob Chemother. 2011; 66(11):2441-3. DOI: 10.1093/jac/dkr370. View

Levy S, FitzGerald G, Macone A . Spread of antibiotic-resistant plasmids from chicken to chicken and from chicken to man. Nature. 1976; 260(5546):40-2. DOI: 10.1038/260040a0. View

Knudsen P, Brandtzaeg P, Hoiby E, Bohlin J, Samuelsen O, Steinbakk M . Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting. PLoS One. 2017; 12(11):e0187618. PMC: 5675440. DOI: 10.1371/journal.pone.0187618. View

Catry B, Laevens H, Devriese L, Opsomer G, De Kruif A . Antimicrobial resistance in livestock. J Vet Pharmacol Ther. 2003; 26(2):81-93. DOI: 10.1046/j.1365-2885.2003.00463.x. View

Bruyndonckx R, Hens N, Aerts M, Goossens H, Abrahantes J, Coenen S . Exploring the association between resistance and outpatient antibiotic use expressed as DDDs or packages. J Antimicrob Chemother. 2015; 70(4):1241-4. DOI: 10.1093/jac/dku525. View

Catry B, Dewulf J, Maes D, Pardon B, Callens B, Vanrobaeys M . Effect of Antimicrobial Consumption and Production Type on Antibacterial Resistance in the Bovine Respiratory and Digestive Tract. PLoS One. 2016; 11(1):e0146488. PMC: 4731056. DOI: 10.1371/journal.pone.0146488. View

Heytens S, Boelens J, Claeys G, DeSutter A, Christiaens T . Uropathogen distribution and antimicrobial susceptibility in uncomplicated cystitis in Belgium, a high antibiotics prescribing country: 20-year surveillance. Eur J Clin Microbiol Infect Dis. 2016; 36(1):105-113. DOI: 10.1007/s10096-016-2776-8. View

Checkley S, Campbell J, Chirino-Trejo M, Janzen E, Waldner C . Associations between antimicrobial use and the prevalence of antimicrobial resistance in fecal Escherichia coli from feedlot cattle in western Canada. Can Vet J. 2010; 51(8):853-61. PMC: 2905004. View

10.

Hara G, Kanj S, Pagani L, Abbo L, Endimiani A, Wertheim H . Ten key points for the appropriate use of antibiotics in hospitalised patients: a consensus from the Antimicrobial Stewardship and Resistance Working Groups of the International Society of Chemotherapy. Int J Antimicrob Agents. 2016; 48(3):239-46. DOI: 10.1016/j.ijantimicag.2016.06.015. View

11.

Mulder M, Kiefte-de Jong J, Goessens W, de Visser H, Hofman A, Stricker B . Risk factors for resistance to ciprofloxacin in community-acquired urinary tract infections due to Escherichia coli in an elderly population. J Antimicrob Chemother. 2016; 72(1):281-289. DOI: 10.1093/jac/dkw399. View

12.

Beeler P, Kuster S, Eschmann E, Weber R, Blaser J . Earlier switching from intravenous to oral antibiotics owing to electronic reminders. Int J Antimicrob Agents. 2015; 46(4):428-33. DOI: 10.1016/j.ijantimicag.2015.06.013. View

13.

Catry B, Latour K, Jans B, Vandendriessche S, Preal R, Mertens K . Risk factors for methicillin resistant Staphylococcus aureus: a multi-laboratory study. PLoS One. 2014; 9(2):e89579. PMC: 3935888. DOI: 10.1371/journal.pone.0089579. View

14.

Bruyndonckx R, Hens N, Aerts M, Goossens H, Latour K, Catry B . Persistence of antimicrobial resistance in respiratory streptococci. J Glob Antimicrob Resist. 2016; 8:6-12. DOI: 10.1016/j.jgar.2016.09.009. View

15.

Zhang L, Huang Y, Zhou Y, Buckley T, Wang H . Antibiotic administration routes significantly influence the levels of antibiotic resistance in gut microbiota. Antimicrob Agents Chemother. 2013; 57(8):3659-66. PMC: 3719697. DOI: 10.1128/AAC.00670-13. View

16.

Hinton M . The sub-specific differentiation of Escherichia coli with particular reference to ecological studies in young animals including man. J Hyg (Lond). 1985; 95(3):595-609. PMC: 2129571. DOI: 10.1017/s0022172400060691. View

17.

Zhao X, Drlica K . A unified anti-mutant dosing strategy. J Antimicrob Chemother. 2008; 62(3):434-6. PMC: 2734085. DOI: 10.1093/jac/dkn229. View

18.

Latour K, Catry B, Broex E, Vankerckhoven V, Muller A, Stroobants R . Indications for antimicrobial prescribing in European nursing homes: results from a point prevalence survey. Pharmacoepidemiol Drug Saf. 2012; 21(9):937-44. DOI: 10.1002/pds.3196. View

19.

Halaby T, Al Naiemi N, Beishuizen B, Verkooijen R, Ferreira J, Klont R . Impact of single room design on the spread of multi-drug resistant bacteria in an intensive care unit. Antimicrob Resist Infect Control. 2017; 6:117. PMC: 5688743. DOI: 10.1186/s13756-017-0275-z. View

20.

Patrick D, Chambers C, Purych D, Chong M, George D, Marra F . Value of an aggregate index in describing the impact of trends in antimicrobial resistance for Escherichia coli. Can J Infect Dis Med Microbiol. 2015; 26(1):33-8. PMC: 4353267. DOI: 10.1155/2015/274298. View