A Re-examination of Otoconia from the Shaker Mouse

Overview

Journal Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 1985 Jan 1

PMID 2994611

Authors

R C Rouse

L G Johnsson

Affiliations

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Abstract

We have studied saccular and utricular otoconia from Shaker-1 and Shaker-2 mice by X-ray diffraction and scanning electron microscopy. In contrast to previous reports, we found that the crystals were composed of calcite rather than polycrystalline hydroxylapatite. These crystals were indistinguishable mineralogically and morphologically from normal mouse otoconia. The reported occurrence of hydroxylapatite otoconia in the Shaker mouse is probably false.

References

Salamat M, Ross M, Peacor D . Otoconial formation in the fetal rat. Ann Otol Rhinol Laryngol. 1980; 89(3 Pt 1):229-38. DOI: 10.1177/000348948008900308. View

Elliott J . The problems of the composition and structure of the mineral components of the hard tissues. Clin Orthop Relat Res. 1973; (93):313-45. DOI: 10.1097/00003086-197306000-00037. View

Ross M, Peacor D, Johnsson L, Allard L . Observations on normal and degenerating human otoconia. Ann Otol Rhinol Laryngol. 1976; 85(3 pt 1):310-26. DOI: 10.1177/000348947608500302. View

Johnsson L, Rouse R, Wright C, Henry P, HAWKINS Jr J . Pathology of neuroepithelial suprastructures of the human inner ear. Am J Otolaryngol. 1982; 3(2):77-90. DOI: 10.1016/s0196-0709(82)80037-9. View

Simpson D . Problems of the composition and structure of the bone minerals. Clin Orthop Relat Res. 1972; 86:260-86. DOI: 10.1097/00003086-197207000-00039. View

Ross M, Peacor D . The nature and crystal growth of otoconia in the rat. Ann Otol Rhinol Laryngol. 1975; 84(1 Pt 1):22-36. DOI: 10.1177/000348947508400105. View

Chou J, Engelbrecht A, von Ilberg C, Juraske P, Scherer H . A study of otoconia of normal mice and shaker mice. Arch Otorhinolaryngol. 1980; 229(3-4):231-43. DOI: 10.1007/BF02565526. View

Anniko M, WROBLEWSKI R . Qualitative and quantitative analysis of otoconia in the normal and in the genetically deaf inner ear. Am J Otol. 1983; 4(4):305-11. View

Johnsson L, HAWKINS Jr J . Otolithic membranes of the saccule and utricle in man. Science. 1967; 157(3795):1454-6. DOI: 10.1126/science.157.3795.1454. View

10.

Blumenthal N, Betts F, Posner A . Formation and structure of Ca-deficient hydroxyapatite. Calcif Tissue Int. 1981; 33(2):111-7. DOI: 10.1007/BF02409422. View

11.

Chickerur N, TUNG M, Brown W . A mechanism for incorporation of carbonate into apatite. Calcif Tissue Int. 1980; 32(1):55-62. DOI: 10.1007/BF02408521. View

12.

Lim D . Formation and fate of the otoconia. Scanning and transmission electron microscopy. Ann Otol Rhinol Laryngol. 1973; 82(1):23-35. DOI: 10.1177/000348947308200109. View

13.

Rouse R, Johnsson L, Wright C, HAWKINS Jr J . Abnormal otoconia and calcification in the labyrinths of deaf Dalmatian dogs. Acta Otolaryngol. 1984; 98(1-2):61-71. DOI: 10.3109/00016488409107535. View