A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats As Revealed by Positron Emission Tomography Using [C]PK11195

Overview

Journal Nucl Med Mol Imaging

Publisher Springer

Date 2018 Jun 27

PMID 29942401

Citations 1

Authors

Miho Ota

Jun Ogura

Shintaro Ogawa

Koichi Kato

Hiroshi Matsuda

Hiroshi Kunugi

Affiliations

Soon will be listed here.

Abstract

Purpose: Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo.

Methods: Ten adult male Fischer F344 rats underwent [C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [C]PK11195 between before and after injection was determined.

Results: There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas.

Conclusions: Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [C]PK11195 PET would clarify the relationships between neuroinflammation and depression.

Citing Articles

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PMID: 34245328 PMC: 8712305. DOI: 10.1007/s00259-021-05379-z.

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