Mutation EthA Confers Co-resistance to Prothionamide and Ethionamide in Both BCG and H37Rv
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Abstract
Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation - EthA - in Bacillus Calmette-Guérin that corresponds with co-resistance to both PRO and ETA, which to the best of our knowledge has not been reported before. Our findings suggest that mutation EthA could be used as a marker site for testing PRO and ETA cross-resistance.
References
1.
Wang F, Langley R, Gulten G, Dover L, Besra G, Jacobs Jr W
. Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007; 204(1):73-8.
PMC: 2118422.
DOI: 10.1084/jem.20062100.
View
2.
Di Perri G, Bonora S
. Which agents should we use for the treatment of multidrug-resistant Mycobacterium tuberculosis?. J Antimicrob Chemother. 2004; 54(3):593-602.
DOI: 10.1093/jac/dkh377.
View
3.
DeBarber A, Mdluli K, Bosman M, Bekker L, Barry 3rd C
. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2000; 97(17):9677-82.
PMC: 16924.
DOI: 10.1073/pnas.97.17.9677.
View
4.
Jenner P, Ellard G, Gruer P, Aber V
. A comparison of the blood levels and urinary excretion of ethionamide and prothionamide in man. J Antimicrob Chemother. 1984; 13(3):267-77.
DOI: 10.1093/jac/13.3.267.
View
5.
Banerjee A, DUBNAU E, Quemard A, Balasubramanian V, Um K, Wilson T
. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science. 1994; 263(5144):227-30.
DOI: 10.1126/science.8284673.
View