Wound Healing, Cellular Regeneration and Plasticity: the Elegans Way

Overview

Journal Int J Dev Biol

Specialties Biology
Reproductive Medicine

Date 2018 Jun 26

PMID 29938761

Citations 6

Authors

Laura Vibert

Anne Daulny

Sophie Jarriault

Affiliations

Soon will be listed here.

Abstract

Regeneration and wound healing are complex processes that allow organs and tissues to regain their integrity and functionality after injury. Wound healing, a key property of epithelia, involves tissue closure that in some cases leads to scar formation. Regeneration, a process rather limited in mammals, is the capacity to regrow (parts of) an organ or a tissue, after damage or amputation. What are the properties of organs and the features of tissue permitting functional regrowth and repair? What are the cellular and molecular mechanisms underlying these processes? These questions are crucial both in fundamental and applied contexts, with important medical implications. The mechanisms and cells underlying tissue repair have thus been the focus of intense investigation. The last decades have seen rapid progress in the domain and new models emerging. Here, we review the fundamental advances and the perspectives that the use of C. elegans as a model have brought to the mechanisms of wound healing and cellular plasticity, axon regeneration and transdifferentiation in vivo.

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References

Sulston J, Horvitz H . Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol. 1977; 56(1):110-56. DOI: 10.1016/0012-1606(77)90158-0. View

Hao J, Yu T, Fujisawa K, Culotti J, Mitani S, Moulder G . C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor. Neuron. 2001; 32(1):25-38. DOI: 10.1016/s0896-6273(01)00448-2. View

Spencer T, Filbin M . A role for cAMP in regeneration of the adult mammalian CNS. J Anat. 2003; 204(1):49-55. PMC: 1571233. DOI: 10.1111/j.1469-7580.2004.00259.x. View

Kim J, Efe J, Zhu S, Talantova M, Yuan X, Wang S . Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A. 2011; 108(19):7838-43. PMC: 3093517. DOI: 10.1073/pnas.1103113108. View

Taffoni C, Pujol N . Mechanisms of innate immunity in C. elegans epidermis. Tissue Barriers. 2015; 3(4):e1078432. PMC: 4681281. DOI: 10.1080/21688370.2015.1078432. View

Wong C, Gaspar-Maia A, Ramalho-Santos M, Pera R . High-efficiency stem cell fusion-mediated assay reveals Sall4 as an enhancer of reprogramming. PLoS One. 2008; 3(4):e1955. PMC: 2278370. DOI: 10.1371/journal.pone.0001955. View

Patel T, Tursun B, Rahe D, Hobert O . Removal of Polycomb repressive complex 2 makes C. elegans germ cells susceptible to direct conversion into specific somatic cell types. Cell Rep. 2012; 2(5):1178-86. PMC: 3529301. DOI: 10.1016/j.celrep.2012.09.020. View

Nix P, Hammarlund M, Hauth L, Lachnit M, Jorgensen E, Bastiani M . Axon regeneration genes identified by RNAi screening in C. elegans. J Neurosci. 2014; 34(2):629-45. PMC: 3870940. DOI: 10.1523/JNEUROSCI.3859-13.2014. View

Lai M, Chen R . Regulation of inflammation by DAPK. Apoptosis. 2013; 19(2):357-63. DOI: 10.1007/s10495-013-0933-4. View

10.

Zou Y, Chiu H, Zinovyeva A, Ambros V, Chuang C, Chang C . Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science. 2013; 340(6130):372-376. PMC: 4074024. DOI: 10.1126/science.1231321. View

11.

Kragl M, Knapp D, Nacu E, Khattak S, Maden M, Epperlein H . Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature. 2009; 460(7251):60-5. DOI: 10.1038/nature08152. View

12.

Xiaowei H, Ninghui Z, Wei X, Yiping T, Linfeng X . The experimental study of hypoxia-inducible factor-1alpha and its target genes in spinal cord injury. Spinal Cord. 2005; 44(1):35-43. DOI: 10.1038/sj.sc.3101813. View

13.

Yan D, Wu Z, Chisholm A, Jin Y . The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009; 138(5):1005-18. PMC: 2772821. DOI: 10.1016/j.cell.2009.06.023. View

14.

Eming S, Martin P, Tomic-Canic M . Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014; 6(265):265sr6. PMC: 4973620. DOI: 10.1126/scitranslmed.3009337. View

15.

Ziegler K, Kurz C, Cypowyj S, Couillault C, Pophillat M, Pujol N . Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Cell Host Microbe. 2009; 5(4):341-52. DOI: 10.1016/j.chom.2009.03.006. View

16.

Chuang M, Goncharov A, Wang S, Oegema K, Jin Y, Chisholm A . The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans. Cell Rep. 2014; 9(3):874-83. PMC: 4250830. DOI: 10.1016/j.celrep.2014.09.054. View

17.

Enes J, Langwieser N, Ruschel J, Carballosa-Gonzalez M, Klug A, Traut M . Electrical activity suppresses axon growth through Ca(v)1.2 channels in adult primary sensory neurons. Curr Biol. 2010; 20(13):1154-64. DOI: 10.1016/j.cub.2010.05.055. View

18.

Hisamoto N, Matsumoto K . Signal transduction cascades in axon regeneration: insights from C. elegans. Curr Opin Genet Dev. 2017; 44:54-60. DOI: 10.1016/j.gde.2017.01.010. View

19.

Oren-Suissa M, Gattegno T, Kravtsov V, Podbilewicz B . Extrinsic Repair of Injured Dendrites as a Paradigm for Regeneration by Fusion in . Genetics. 2017; 206(1):215-230. PMC: 5419471. DOI: 10.1534/genetics.116.196386. View

20.

Huang L, Sternberg P . Genetic dissection of developmental pathways. WormBook. 2007; :1-19. PMC: 4781082. DOI: 10.1895/wormbook.1.88.2. View