Epstein-Barr Virus-Induced Metabolic Rearrangements in Human B-Cell Lymphomas

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2018 Jun 26

PMID 29937761

Citations 23

Authors

Pier P Piccaluga

Alessandra Weber

Maria R Ambrosio

Yonis Ahmed

Lorenzo Leoncini

Affiliations

Soon will be listed here.

Abstract

Tumor metabolism has been the object of several studies in the past, leading to the pivotal observation of a consistent shift toward aerobic glycolysis (so-called Warburg effect). More recently, several additional investigations proved that tumor metabolism is profoundly affected during tumorigenesis, including glucose, lipid and amino-acid metabolism. It is noticeable that metabolic reprogramming can represent a suitable therapeutic target in many cancer types. Epstein-Barr virus (EBV) was the first virus linked with cancer in humans when Burkitt lymphoma (BL) was described. Besides other well-known effects, it was recently demonstrated that EBV can induce significant modification in cell metabolism, which may lead or contribute to neoplastic transformation of human cells. Similarly, virus-induced tumorigenesis is characterized by relevant metabolic abnormalities directly induced by the oncoviruses. In this article, the authors critically review the most recent literature concerning EBV-induced metabolism alterations in lymphomas.

Citing Articles

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