Role of T-Helper 9 Cells in Chronic Hepatitis C-Infected Patients

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2018 Jun 26

PMID 29937515

Citations 8

Authors

Mohamed E Ali

Omnia El-Badawy

Noha A Afifi

Abeer Sharaf Eldin

Elham Ahmed Hassan

Hamada M Halby

Mohamed Ahmed El-Mokhtar

Affiliations

Soon will be listed here.

Abstract

Hepatitis C virus is a hepatotropic virus that is transmitted parenterally. Viral infections are usually associated with modulations of the immune cells, leading to enhanced viral survival and spreading, and accordingly, life-threatening complications. Recently, it has been proposed that a new subset of T-helper, named T-helper 9, is involved in the pathogenesis of different immunopathological conditions, such as allergies, tumors, and viral infections. Some studies reported a protective role, and others described a pathogenic potential for the T-helper 9 cells. Here, we present evidence that T-helper 9 cells are dynamically increased with increasing the pathogenic strategy for hepatitis C virus (HCV). Furthermore, viral clearance is associated with a decrease in T-helper 9. The increase in T-helper 9 was paralleled with an increase in its receptor expression. Taken together, our data suggest that T-helper 9 cells play an important role in the pathogenesis of HCV, and is directly associated with HCV-related complications.

Citing Articles

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