Total Calcium (Dietary and Supplementary) Intake and Prostate Cancer: a Systematic Review and Meta-Analysis

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2018 Jun 26

PMID 29936714

Citations 8

Authors

Shoboo Rahmati

Milad Azami

Ali Delpisheh

Mohammad Reza Hafezi Ahmadi

Kourosh Sayehmiri

Affiliations

Soon will be listed here.

Abstract

Background: Controversial results have been reported concerning the influence of calcium intake on prostate cancer risk. The aim of this study was to determine any association between total calcium (in the diet and in supplements) intake and prostate cancer. Materials and Methods: The present systematic review and meta-analysis study was carried out following a PRISMA guidelines. Two reviewers independently using MeSH keywords searched international databases including PubMed, Science Direct, Cochrane, EMBASE, Web of Science, CINAHL, EBSCO and search engines such as Google Scholar. The searches were performed without any time limit until May 2016. The results were pooled using a random effects model and homogeneity was confirmed using the Q test and I2 index. Subgroup analyses was performed according to continents and study designs. The data were analyzed using STATA software version 3.2, with p<0.05 considered significant. Result: Overall, 12 studies with a total sample size of 905,046 were entered into the final meta-analysis. The main age range of the participants was 50 to 70 years. The relative risks (RR) for total calcium with total prostate cancer, localized prostate cancer, and advance prostate cancer were estimated to be 1.15 (95% CI: 1.04-3.46), 1.05 (95% CI: 0.96-1.14), and 1.15 (95% CI: 0.89-1.50), respectively. Only the relationship between total calcium and total prostate cancer was significant (P<0.05). Conclusions: High calcium intake can be considered as a risk factor for total prostate cancer. Therefore, calcium intake might be a target for prevention.

Citing Articles

Calcium deficiency and its implications for cardiovascular disease and cancer: Strategies for resolution via agronomic fortification.

Cheng L, Lian J, Ding Y, Wang X, Munir M, Ullah S Food Sci Nutr. 2024; 12(11):8594-8607.

PMID: 39619946 PMC: 11606831. DOI: 10.1002/fsn3.4464.

Calcium Intake and the Pancreatic Cancer Risk: A Systematic Review and Meta-Analysis of Observational Studies.

Bahrami A, Mohammadzadeh M, Abdi F, Paydareh A, Khalesi S, Hejazi E Clin Nutr Res. 2024; 13(4):284-294.

PMID: 39526207 PMC: 11543454. DOI: 10.7762/cnr.2024.13.4.284.

Nutrigenomics and microbiome shaping the future of personalized medicine: a review article.

Kassem N, Abdelmegid Y, El-Sayed M, Sayed R, Abdel-Aalla M, Kassem H J Genet Eng Biotechnol. 2023; 21(1):134.

PMID: 37993702 PMC: 10665279. DOI: 10.1186/s43141-023-00599-2.

Dietary inflammatory index and prostate cancer risk: MCC-Spain study.

Lozano-Lorca M, Salcedo-Bellido I, Olmedo-Requena R, Castano-Vinyals G, Amiano P, Shivappa N Prostate Cancer Prostatic Dis. 2022; 25(3):568-575.

PMID: 35418209 DOI: 10.1038/s41391-022-00532-7.

The association of minerals intake in three meals with cancer and all-cause mortality: the U.S. National Health and Nutrition Examination Survey, 2003-2014.

Xu X, Wei W, Xu J, Huang J, Li L, Han T BMC Cancer. 2021; 21(1):912.

PMID: 34380458 PMC: 8359108. DOI: 10.1186/s12885-021-08643-5.

References

Rodriguez C, McCullough M, Mondul A, Jacobs E, Fakhrabadi-Shokoohi D, Giovannucci E . Calcium, dairy products, and risk of prostate cancer in a prospective cohort of United States men. Cancer Epidemiol Biomarkers Prev. 2003; 12(7):597-603. View

Park S, Murphy S, Wilkens L, Stram D, Henderson B, Kolonel L . Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study. Am J Epidemiol. 2007; 166(11):1259-69. DOI: 10.1093/aje/kwm269. View

Ganmaa D, Li X, Wang J, Qin L, Wang P, Sato A . Incidence and mortality of testicular and prostatic cancers in relation to world dietary practices. Int J Cancer. 2002; 98(2):262-7. DOI: 10.1002/ijc.10185. View

Rowland G, Schwartz G, John E, Ingles S . Calcium intake and prostate cancer among African Americans: effect modification by vitamin D receptor calcium absorption genotype. J Bone Miner Res. 2011; 27(1):187-94. PMC: 3234334. DOI: 10.1002/jbmr.505. View

Giovannucci E, Liu Y, Platz E, Stampfer M, Willett W . Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer. 2007; 121(7):1571-8. PMC: 2430098. DOI: 10.1002/ijc.22788. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010; 8(5):336-41. DOI: 10.1016/j.ijsu.2010.02.007. View

Park Y, Mitrou P, Kipnis V, Hollenbeck A, Schatzkin A, Leitzmann M . Calcium, dairy foods, and risk of incident and fatal prostate cancer: the NIH-AARP Diet and Health Study. Am J Epidemiol. 2007; 166(11):1270-9. DOI: 10.1093/aje/kwm268. View

Ahn J, Albanes D, Peters U, Schatzkin A, Lim U, Freedman M . Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2007; 16(12):2623-30. DOI: 10.1158/1055-9965.EPI-07-0601. View

Kristal A, Arnold K, Neuhouser M, Goodman P, Platz E, Albanes D . Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial. Am J Epidemiol. 2010; 172(5):566-77. PMC: 2950820. DOI: 10.1093/aje/kwq148. View

10.

Ma J, Giovannucci E, Pollak M, Chan J, Gaziano J, Willett W . Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. J Natl Cancer Inst. 2001; 93(17):1330-6. DOI: 10.1093/jnci/93.17.1330. View

11.

Grant W . An ecologic study of dietary links to prostate cancer. Altern Med Rev. 1999; 4(3):162-9. View

12.

Kesse E, Bertrais S, Astorg P, Jaouen A, Arnault N, Galan P . Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study. Br J Nutr. 2006; 95(3):539-45. DOI: 10.1079/bjn20051670. View

13.

Wiseman M . The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008; 67(3):253-6. DOI: 10.1017/S002966510800712X. View

14.

Wilson K, Shui I, Mucci L, Giovannucci E . Calcium and phosphorus intake and prostate cancer risk: a 24-y follow-up study. Am J Clin Nutr. 2014; 101(1):173-83. PMC: 4266887. DOI: 10.3945/ajcn.114.088716. View

15.

Rohrmann S, Platz E, Kavanaugh C, Thuita L, Hoffman S, Helzlsouer K . Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. Cancer Causes Control. 2007; 18(1):41-50. DOI: 10.1007/s10552-006-0082-y. View

16.

Butler L, Wong A, Koh W, Wang R, Yuan J, Yu M . Calcium intake increases risk of prostate cancer among Singapore Chinese. Cancer Res. 2010; 70(12):4941-8. PMC: 4219618. DOI: 10.1158/0008-5472.CAN-09-4544. View

17.

Qin L, He K, Xu J . Milk consumption and circulating insulin-like growth factor-I level: a systematic literature review. Int J Food Sci Nutr. 2009; 60 Suppl 7:330-40. DOI: 10.1080/09637480903150114. View

18.

Rahmati S, Delpishe A, Azami M, Hafezi Ahmadi M, Sayehmiri K . Maternal Anemia during pregnancy and infant low birth weight: A systematic review and Meta-analysis. Int J Reprod Biomed. 2017; 15(3):125-134. PMC: 5447828. View

19.

Aune D, Lau R, Chan D, Vieira R, Greenwood D, Kampman E . Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol. 2011; 23(1):37-45. DOI: 10.1093/annonc/mdr269. View

20.

Zhang J, Kesteloot H . Milk consumption in relation to incidence of prostate, breast, colon, and rectal cancers: is there an independent effect?. Nutr Cancer. 2005; 53(1):65-72. DOI: 10.1207/s15327914nc5301_8. View