Current Progress in Asymmetric Biginelli Reaction: an Update

Overview

Journal Mol Divers

Date 2018 Jun 25

PMID 29936682

Citations 6

Authors

Majid M Heravi

Razieh Moradi

Leyla Mohammadkhani

Borzou Moradi

Affiliations

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Abstract

The Biginelli reaction, involving a three-component reaction of an aromatic aldehyde, urea and ethyl acetoacetate, has emerged as an extremely useful synthetic tool to organic chemists for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones and related heterocyclic compounds. In the past decades, the asymmetric variants of this reaction have been at the forefront of investigations in several research groups. In 2013, we highlighted the developments occurred in the asymmetric version of the Biginelli reaction. This review article focuses on the recent developments of asymmetric Biginelli reaction covers the literature going back to 2012.

Citing Articles

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction.

Diaz-Fernandez M, Algarra M, Calvo-Losada S, Quirante J, Sarabia F, Pino-Gonzalez M Molecules. 2024; 29(16).

PMID: 39202943 PMC: 11357475. DOI: 10.3390/molecules29163864.

Precision in stereochemistry: the integral role of catalytic asymmetric Biginelli reaction in crafting enantiomerically pure dihydropyrimidinones.

Bendi A, Bhathiwal A, Tiwari A, Rao G, Afshari M Mol Divers. 2024; 28(6):4441-4466.

PMID: 38539026 DOI: 10.1007/s11030-024-10827-7.

Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions.

Sanchez-Sancho F, Escolano M, Gavina D, Csaky A, Sanchez-Rosello M, Diaz-Oltra S Pharmaceuticals (Basel). 2022; 15(8).

PMID: 36015096 PMC: 9413519. DOI: 10.3390/ph15080948.

Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids.

Bukhari S, Ejaz H, Elsherif M, Jankovic N Molecules. 2022; 27(9).

PMID: 35566289 PMC: 9099458. DOI: 10.3390/molecules27092939.

Overview on magnetically recyclable ferrite nanoparticles: synthesis and their applications in coupling and multicomponent reactions.

Tandon R, Tandon N, Patil S RSC Adv. 2022; 11(47):29333-29353.

PMID: 35479579 PMC: 9040805. DOI: 10.1039/d1ra03874e.

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