Herpesvirus Sylvilagus Infects Both B and T Lymphocytes in Vivo

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1985 Oct 1

PMID 2993667

Citations 4

Authors

W J Kramp

P Medveczky

C Mulder

H C Hinze

J L Sullivan

Affiliations

Soon will be listed here.

Abstract

Herpesvirus sylvilagus infection of cottontail rabbits (Sylvilagus floridanus) was studied as a model of herpesvirus-induced lymphoproliferative disorders. Leukocytosis, splenomegaly, proliferation of T cells and virus production by lymphocytes characterized this infectious mononucleosis-like disease. Approximately two copies of circular herpesvirus sylvilagus genomes per cell were detected in spleen cells at 2 weeks postinfection, and circular genomes could still be observed after 4 months. Circular viral genomes were found in both B and T lymphocytes. Small amounts of linear viral DNA (0.1 to 0.3 copies per cell) were also detected in both B and T cells. These results indicated that the virus did not replicate in the majority of lymphocytes in vivo. Herpesvirus sylvilagus infection in cottontail rabbits could be useful as a model for studying the complex virus-host relationships of lymphotropic herpesviruses and perhaps as an animal model for Epstein-Barr virus infection in humans.

Citing Articles

Equine gammaherpesvirus 2 (EHV2) is latent in B lymphocytes.

Drummer H, Reubel G, Studdert M Arch Virol. 1996; 141(3-4):495-504.

PMID: 8645091 DOI: 10.1007/BF01718313.

Genome structure of cottontail rabbit herpesvirus.

Cebrian J, Berthelot N, Laithier M J Virol. 1989; 63(2):523-31.

PMID: 2911115 PMC: 247720. DOI: 10.1128/JVI.63.2.523-531.1989.

Arrangement of repetitive sequences in the genome of herpesvirus Sylvilagus.

Medveczky M, Geck P, Clarke C, Byrnes J, Sullivan J, Medveczky P J Virol. 1989; 63(2):1010-4.

PMID: 2911114 PMC: 247786. DOI: 10.1128/JVI.63.2.1010-1014.1989.

B cell activation and the establishment of Epstein-Barr virus latency.

Hurley E, Thorley-Lawson D J Exp Med. 1988; 168(6):2059-75.

PMID: 2848918 PMC: 2189139. DOI: 10.1084/jem.168.6.2059.

References

Werner F, Bauer I, Fleckenstein B . Structure of nonintegrated, circular Herpesvirus saimiri and Herpesvirus ateles genomes in tumor cell lines and in vitro-transformed cells. J Virol. 1982; 44(1):295-310. PMC: 256265. DOI: 10.1128/JVI.44.1.295-310.1982. View

Sullivan J, Medveczky P, Forman S, Baker S, Monroe J, Mulder C . Epstein-Barr-virus induced lymphoproliferation. Implications for antiviral chemotherapy. N Engl J Med. 1984; 311(18):1163-7. DOI: 10.1056/NEJM198411013111806. View

Ooka T, Calender A, De Turenne M, Daillie J . Effect of arabinofuranosylthymine on the replication of Epstein-Barr virus and relationship with a new induced thymidine kinase activity. J Virol. 1983; 46(1):187-95. PMC: 255107. DOI: 10.1128/JVI.46.1.187-195.1983. View

Wegner D, Hinze H . Virus--host-cell relationship of Herpesvirus sylvilagus with cottontail rabbit leukocytes. Int J Cancer. 1974; 14(5):567-75. DOI: 10.1002/ijc.2910140502. View

Hanto D, Frizzera G, Sakamoto K, Purtilo D, Balfour Jr H, Simmons R . Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. N Engl J Med. 1982; 306(15):913-8. DOI: 10.1056/NEJM198204153061506. View

Sell S, Skaletsky E, Holdbrook R, Linthicum D, Raffel C . Alternative hypotheses of lymphocyte surface immunoglobulin expression, B lymphocyte activation and B lymphocyte differentiation. Immunol Rev. 1980; 52:141-79. DOI: 10.1111/j.1600-065x.1980.tb00334.x. View

Rinaldo Jr C, Black P, Hirsch M . Interaction of cytomegalovirus with leukocytes from patients with mononucleosis due to cytomegalovirus. J Infect Dis. 1977; 136(5):667-78. DOI: 10.1093/infdis/136.5.667. View

Bayliss G, Wolf H . The regulated expression of Epstein-Barr virus. III. Proteins specified by EBV during the lytic cycle. J Gen Virol. 1981; 56(Pt 1):105-18. DOI: 10.1099/0022-1317-56-1-105. View

Sixbey J, Pagano J . Epstein-Barr virus transformation of human B lymphocytes despite inhibition of viral polymerase. J Virol. 1985; 53(1):299-301. PMC: 255037. DOI: 10.1128/JVI.53.1.299-301.1985. View

10.

Daniel M, Melendez L, Hunt R, King N, Anver M, Fraser C . Herpesvirus saimiri: VII. Induction of malignant lymphoma in New Zealand white rabbits. J Natl Cancer Inst. 1974; 53(6):1803-7. View

11.

Rziha H, Bauer B . Circular forms of viral DNA in Marek's disease virus-transformed lymphoblastoid cells. Arch Virol. 1982; 72(3):211-6. DOI: 10.1007/BF01348966. View

12.

Hsiung G . Expression of herpesvirus in adherent cells derived from bone marrow of latently infected guinea pigs. Am J Pathol. 1978; 91(3):483-96. PMC: 2018305. View

13.

Hinze H . Induction of lymphoid hyperplasia and lymphoma-like disease in rabbits by Herpesvirus sylvilagus. Int J Cancer. 1971; 8(3):514-22. DOI: 10.1002/ijc.2910080320. View

14.

Spieker J, Yuill T . Herpesvirus sylvilagus in cottontail rabbits: evidence of shedding but not transplacental transmission. J Wildl Dis. 1977; 13(1):85-9. DOI: 10.7589/0090-3558-13.1.85. View

15.

Spieker J, Yuill T . Herpesvirus sylvilagus in cottontail rabbits: antibody prevalence and flea burden relationships. J Wildl Dis. 1976; 12(3):310-4. DOI: 10.7589/0090-3558-12.3.310. View

16.

Sullivan J, Byron K, Brewster F, Baker S, Ochs H . X-linked lymphoproliferative syndrome. Natural history of the immunodeficiency. J Clin Invest. 1983; 71(6):1765-78. PMC: 370382. DOI: 10.1172/jci110932. View

17.

Falk L, Johnson D, Deinhardt F . Transformation of marmoset lymphocytes in vitro with Herpesvirus ateles. Int J Cancer. 1978; 21(5):652-7. DOI: 10.1002/ijc.2910210517. View

18.

Jondal M, Klein G . Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes. J Exp Med. 1973; 138(6):1365-78. PMC: 2139459. DOI: 10.1084/jem.138.6.1365. View

19.

Hunt R, Melendez L, Garcia F, TRUM B . Pathologic features of Herpesvirus ateles lymphoma in cotton-topped marmosets (Saguinus oedipus). J Natl Cancer Inst. 1972; 49(6):1631-9. DOI: 10.1093/jnci/49.6.1631. View

20.

Hunt R, Melendez L, King N, GILMORE C, Daniel M, Williamson M . Morphology of a disease with features of malignant lymphoma in marmosets and owl monkeys inoculated with Herpesvirus saimiri. J Natl Cancer Inst. 1970; 44(2):447-65. View