Tau Uptake in Agrammatic Primary Progressive Aphasia with and Without Apraxia of Speech

Overview

Journal Eur J Neurol

Publisher Wiley

Specialty Neurology

Date 2018 Jun 24

PMID 29935044

Citations 9

Authors

R L Utianski

J L Whitwell

C G Schwarz

J R Duffy

H Botha

H M Clark

M M Machulda

M L Senjem

D S Knopman

R C Petersen

C R Jack Jr

V J Lowe

K A Josephs

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: The non-fluent/agrammatic variant of primary progressive aphasia (agPPA) is a heterogeneous diagnosis wherein some individuals have apraxia of speech (AOS). When agPPA includes AOS, a tauopathy is the likely underlying pathology. Recently, [18F]AV-1451 was developed for the in-vivo assessment of tau. In this study, we compared patterns of tau tracer uptake in patients with agPPA with and without AOS.

Methods: Nine patients with agPPA (four without AOS) underwent tau positron emission tomography imaging with [18F]AV-1451. Uptake of [18F]AV-1451 was assessed as cortical to cerebellar crus ratio (standard uptake value ratio) in cortical regions of interest measured using the MCALT atlas and compared voxel-wise in SPM12. Each patient was age- and sex-matched to three controls.

Results: The agPPA without AOS showed uptake in the left frontal and temporal lobes, whereas agPPA with AOS showed uptake in the bilateral supplementary motor areas, frontal lobes, precuneus and precentral gyrus relative to controls. The left precentral gyrus had uptake in agPPA with AOS relative to those without AOS.

Conclusions: This cross-sectional study suggests that [18F]AV-1451 uptake in the precentral gyrus is implicated in AOS in agPPA.

Citing Articles

Neuroimaging in Frontotemporal Dementia: Heterogeneity and Relationships with Underlying Neuropathology.

Peet B, Spina S, Mundada N, La Joie R Neurotherapeutics. 2021; 18(2):728-752.

PMID: 34389969 PMC: 8423978. DOI: 10.1007/s13311-021-01101-x.

Neuropsychological Profiles of Patients with Progressive Apraxia of Speech and Aphasia.

Polsinelli A, Machulda M, Martin P, Duffy J, Clark H, Butts A J Int Neuropsychol Soc. 2021; 28(5):441-451.

PMID: 34289926 PMC: 8986341. DOI: 10.1017/S1355617721000692.

Primary Progressive Apraxia of Speech: From Recognition to Diagnosis and Care.

Duffy J, Utianski R, Josephs K Aphasiology. 2021; 35(4):560-591.

PMID: 34219857 PMC: 8247786. DOI: 10.1080/02687038.2020.1787732.

Modelling speech motor programming and apraxia of speech in the DIVA/GODIVA neurocomputational framework.

Miller H, Guenther F Aphasiology. 2021; 35(4):424-441.

PMID: 34108793 PMC: 8183977. DOI: 10.1080/02687038.2020.1765307.

Differential Diagnosis of Apraxia of Speech in Children and Adults: A Scoping Review.

Allison K, Cordella C, Iuzzini-Seigel J, Green J J Speech Lang Hear Res. 2020; 63(9):2952-2994.

PMID: 32783767 PMC: 7890226. DOI: 10.1044/2020_JSLHR-20-00061.

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