Education and Employment Trajectories from Childhood to Adulthood in Individuals with 22q11.2 Deletion Syndrome

Overview

Journal Eur Child Adolesc Psychiatry

Specialties Pediatrics
Psychiatry

Date 2018 Jun 24

PMID 29934817

Citations 14

Authors

Mariela Mosheva

Virginie Pouillard

Yael Fishman

Lydia Dubourg

Dafna Sofrin-Frumer

Yaffa Serur

Abraham Weizman

Stephan Eliez

Doron Gothelf

Maude Schneider

Affiliations

Soon will be listed here.

Abstract

22q11.2 deletion syndrome (22q11.2DS) is the most common known microdeletion in humans occurring in 1 out of 2000-4000 live births, with increasing numbers of individuals with the microdeletion living into adulthood. The aim of the study was to explore the education and employment trajectories of individuals with 22q11.2DS from childhood to adulthood in a large cohort composed of two significant samples. 260 individuals with 22q11.2DS, 134 male and 126 female, aged 5-59 years (mean age 21.3 ± 10.8 years) were evaluated at two sites, Geneva (GVA) and Tel Aviv (TA). Psychiatric comorbidities, IQ score, and adaptive functioning were assessed using gold-standard diagnostic tools. Demographic factors, such as data about education, employment, marital status, and living status, were collected. Children entering elementary school (5-12 years) were significantly more likely to attend a mainstream school, while adolescents were significantly more likely to attend special education schools (p < 0.005). Cognitive abilities, and not adaptive functioning, predicted school placement. Among adults with 22q11.2DS (n = 138), 57 (41.3%) were unemployed, 46 (33.3%) were employed in open market employment, and 35 (25.4%) worked in assisted employment. In adulthood, adaptive functioning more than cognitive abilities predicted employment. Surprisingly, psychotic spectrum disorders were not found to be associated with employment. Individuals with 22q11.2DS are characterized by heterogeneity in educational and employment profiles. We found that cognitive abilities and adaptive functioning, and not the presence of psychiatric disorders, are key factors in school placement and employment. These factors should, therefore, be taken into account when planning optimal development of individuals with 22q11.2DS.

Citing Articles

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Jayman M, Edmonds S, Gudbrandsen M Behav Sci (Basel). 2025; 15(1).

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Obesity and metabolic syndrome in adults with a 22q11.2 microdeletion.

Jaspers Faijer-Westerink H, von Scheibler E, van Rossum E, van Haelst M, Vingerhoets C, van Amelsvoort T Int J Obes (Lond). 2024; .

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Cognitive, adaptive and daily life functioning in adults with 22q11.2 deletion syndrome.

Vingerhoets C, Ruiz-Fernandez J, von Scheibler E, Vergaelen E, Volbragt N, Soons N BJPsych Open. 2024; 10(6):e203.

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The clinical course of individuals with 22q11.2 deletion syndrome converting to psychotic disorders: a long-term retrospective follow-up.

Kulikova K, Schneider M, McDonald McGinn D, Dar S, Taler M, Schwartz-Lifshitz M Eur Child Adolesc Psychiatry. 2024; 33(12):4371-4379.

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Work participation in adults with rare genetic diseases - a scoping review.

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