Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?

Overview

Journal Eur Med J Hepatol

Date 2018 Jun 23

PMID 29930864

Citations 28

Authors

Joel Grunhut

Wei Wang

Berk Aykut

Inderdeep Gakhal

Alejandro Torres-Hernandez

George Miller

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease that is characterised by steatosis, chronic inflammation, and hepatocellular injury with or without fibrosis. The role and activation of macrophages in the pathogenesis of NASH is complex and is being studied for possible therapeutic options to help the millions of people diagnosed with the disease. The purpose of this review is to discuss the pathogenesis of NASH through the activation and role of Kupffer cells and other macrophages in causing inflammation and progression of NASH. Furthermore, this review aims to outline some of the current therapeutic options targeting the pathogenesis of NASH.

Citing Articles

Hepatic Macrophages as Targets for the MSC-Based Cell Therapy in Non-Alcoholic Steatohepatitis.

Kholodenko I, Yarygin K Biomedicines. 2023; 11(11).

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Mitochondrial Dysfunction-Associated Mechanisms in the Development of Chronic Liver Diseases.

Arumugam M, Gopal T, Kalari Kandy R, Boopathy L, Perumal S, Ganesan M Biology (Basel). 2023; 12(10).

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MSC-sEV Treatment Polarizes Pro-Fibrotic M2 Macrophages without Exacerbating Liver Fibrosis in NASH.

Zhang B, Zhang B, Lai R, Sim W, Lam K, Lim S Int J Mol Sci. 2023; 24(9).

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Vsig4 resident single-Kupffer cells improve hepatic inflammation and fibrosis in NASH.

Li H, Fu S, Wu J, Li Z, Xu M Inflamm Res. 2023; 72(4):669-682.

PMID: 36745210 DOI: 10.1007/s00011-023-01696-1.

Pathogenesis from Inflammation to Cancer in NASH-Derived HCC.

Yu S, Wang J, Zheng H, Wang R, Johnson N, Li T J Hepatocell Carcinoma. 2022; 9:855-867.

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