Gut Microbiome in Type 1 Diabetes: A Comprehensive Review

Overview

Journal Diabetes Metab Res Rev

Specialty Endocrinology

Date 2018 Jun 22

PMID 29929213

Citations 96

Authors

Peilin Zheng

Zhixia Li

Zhiguang Zhou

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome-wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D has been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D-triggering factors, especially environmental factors. In this review, we summarize the current aetiological and mechanism studies of gut microbiome in T1D. A better understanding of the role of gut microbiome in T1D may provide us with powerful prognostic and therapeutic tools in the near future.

Citing Articles

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