NOS3 Polymorphisms and Chronic Kidney Disease

Overview

Journal J Bras Nefrol

Specialty Nephrology

Date 2018 Jun 22

PMID 29927456

Citations 7

Authors

Alejandro Marin Medina

Eduardo Esteban Zubero

Moises Alejandro Alatorre Jimenez

Sara Anabel Alonso Barragan

Carlos Arturo Lopez Garcia

Jose Juan Gomez Ramos

Juan Francisco Santoscoy Gutierrez

Zurisadai Gonzalez Castillo

Affiliations

Soon will be listed here.

Abstract

Chronic kidney disease (CKD) is a multifactorial pathophysiologic irreversible process that often leads to a terminal state in which the patient requires renal replacement therapy. Most cases of CKD are due to chronic-degenerative diseases and endothelial dysfunction is one of the factors that contribute to its pathophysiology. One of the most important mechanisms for proper functioning of the endothelium is the regulation of the synthesis of nitric oxide. This compound is synthesized by the enzyme nitric oxide synthase, which has 3 isoforms. Polymorphisms in the NOS3 gene have been implicated as factors that alter the homeostasis of this mechanism. The Glu298Asp polymorphisms 4 b/a and -786T>C of the NOS3 gene have been associated with a more rapid deterioration of kidney function in patients with CKD. These polymorphisms have been evaluated in patients with CKD of determined and undetermined etiology and related to a more rapid deterioration of kidney function.

Citing Articles

Mitochondrial related variants associated with cardiovascular traits.

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Genetic variants affecting mitochondrial function provide further insights for kidney disease.

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Association between the Polymorphisms rs2070744, 4b/a and rs1799983 of the Gene with Chronic Kidney Disease of Uncertain or Non-Traditional Etiology in Mexican Patients.

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Characterization of hepatic fatty acids using magnetic resonance spectroscopy for the assessment of treatment response to metformin in an eNOS mouse model of metabolic nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

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Association between nitric oxide synthase T-786C genetic polymorphism and chronic kidney disease: Meta-analysis incorporating trial sequential analysis.

Hsiao P, Chiu C, Tsai D, Ko P, Chen Y, Cheng H PLoS One. 2021; 16(10):e0258789.

PMID: 34662360 PMC: 8523046. DOI: 10.1371/journal.pone.0258789.

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