Exploring the Relationship Between Environmental Enteric Dysfunction and Oral Vaccine Responses

Overview

Journal Future Microbiol

Specialties Infectious Diseases
Microbiology

Date 2018 Jun 22

PMID 29926747

Citations 33

Authors

James A Church

Edward Pk Parker

Margaret N Kosek

Gagandeep Kang

Nicholas C Grassly

Paul Kelly

Andrew J Prendergast

Affiliations

Soon will be listed here.

Abstract

Oral vaccines significantly underperform in low-income countries. One possible contributory factor is environmental enteric dysfunction (EED), a subclinical disorder of small intestinal structure and function among children living in poverty. Here, we review studies describing oral vaccine responses and EED. We identified eight studies evaluating EED and oral vaccine responses. There was substantial heterogeneity in study design and few consistent trends emerged. Four studies reported a negative association between EED and oral vaccine responses; two showed no significant association; and two described a positive correlation. Current evidence is therefore insufficient to determine whether EED contributes to oral vaccine underperformance. We identify roadblocks in the field and future research needs, including carefully designed studies those can investigate this hypothesis further.

Citing Articles

Genetic variation in environmental enteropathy and stunting in Zambian children: A pilot genome wide association study using the H3Africa chip.

Mweetwa M, Haritunians T, Dube S, Chandwe K, Amadi B, Zyambo K PLoS One. 2023; 18(9):e0291311.

PMID: 37756315 PMC: 10529557. DOI: 10.1371/journal.pone.0291311.

Investigating the Impact of Supplemented to Kenyan Breastfeeding Mothers on Maternal and Infant Health: A Cluster Randomized Single-Blinded Controlled Pilot Trial Protocol.

Mogaka J, Owuor P, Odhiambo S, Waterman C, McGuire M, Fuchs G JPGN Rep. 2023; 3(3):e237.

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Lack of Associations between Environmental Exposures and Environmental Enteric Dysfunction among 18-Month-Old Children in Rural Malawi.

Liu Z, Fan Y, Ashorn P, Chingwanda C, Maleta K, Hallamaa L Int J Environ Res Public Health. 2022; 19(17).

PMID: 36078607 PMC: 9517768. DOI: 10.3390/ijerph191710891.

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.

Kummerlowe C, Mwakamui S, Hughes T, Mulugeta N, Mudenda V, Besa E Sci Transl Med. 2022; 14(660):eabi8633.

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C-sucrose breath test for the non-invasive assessment of environmental enteropathy in Zambian adults.

Schillinger R, Mwakamui S, Mulenga C, Tembo M, Hodges P, Besa E Front Med (Lausanne). 2022; 9:904339.

PMID: 35966866 PMC: 9372340. DOI: 10.3389/fmed.2022.904339.

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