TRPM8 and Prostate: a Cold Case?

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2018 Jun 22

PMID 29926226

Citations 15

Authors

Lucile Noyer

Guillaume P Grolez

Natalia Prevarskaya

Dimitra Gkika

Loic Lemonnier

Affiliations

Soon will be listed here.

Abstract

While originally cloned from the prostate in 2001, transient receptor potential, melastatin member 8 (TRPM8) has since been identified as the cold/menthol receptor in the peripheral nervous system. This discovery has led to hundreds of studies regarding the role of this channel in pain and thermosensation phenomena, while relegating TRPM8 involvement in cancer to a secondary role. Despite these findings, there is growing evidence that TRPM8 should be carefully studied within the frame of carcinogenesis, especially in the prostate, where it is highly expressed and where many teams have confirmed variations in its expression during cancer progression. Its regulation by physiological factors, such as PSA and androgens, has proved that TRPM8 can exhibit an activity beyond that of a cold receptor, thus explaining how the channel can be activated in organs not exposed to temperature variations. With this review, we aim to provide a brief overview of the current knowledge regarding the complex roles of TRPM8 in prostate carcinogenesis and to show that this research path still represents a "hot" topic with potential clinical applications in the short term.

Citing Articles

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies.

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Tune the channel: TRPM8 targeting in prostate cancer.

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Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans.

Hsieh P, Dang V, Vollger M, Mao Y, Huang T, Dishuck P Nat Commun. 2021; 12(1):5118.

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TRPM8 protein expression in hormone naïve local and lymph node metastatic prostate cancer.

Lunardi A, Barbareschi M, Carbone F, Morelli L, Brunelli M, Fortuna N Pathologica. 2021; 113(2):95-101.

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Binding of Androgen- and Estrogen-Like Flavonoids to Their Cognate (Non)Nuclear Receptors: A Comparison by Computational Prediction.

DArrigo G, Gianquinto E, Rossetti G, Cruciani G, Lorenzetti S, Spyrakis F Molecules. 2021; 26(6).

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