Effects of Nicardipine on Aldosterone Release and Pressor Mechanisms

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1985 Jan 1

PMID 2992564

Citations 2

Authors

H L Elliott

F Pasanisi

J L Reid

Affiliations

Soon will be listed here.

Abstract

This study evaluated the effects of nicardipine, following intravenous infusion and oral administration, on the pressor and aldosterone responses to infused angiotensin II. Six healthy, normotensive male subjects were studied. Following administration of nicardipine, no significant change in blood pressure was seen. Nicardipine attenuated the pressor response produced by intravenous administration of angiotensin. Nicardipine did not inhibit the aldosterone response to angiotensin.

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Molecular and clinical investigations in patients with low-renin hypertension.

Mackenzie I, Brown M Clin Exp Nephrol. 2008; 13(1):1-8.

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Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders.

Sorkin E, Clissold S Drugs. 1987; 33(4):296-345.

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