Characteristics and Survival Outcomes Related to the Infra-pyloric Lymph Node Status of Gastric Cancer Patients

Overview

Journal World J Surg Oncol

Publisher Biomed Central

Specialties General Surgery
Oncology

Date 2018 Jun 22

PMID 29925390

Citations 6

Authors

Wei-Han Zhang

Xiao-Hai Song

Xin-Zu Chen

Kun Yang

Kai Liu

Zhi-Xin Chen

Zong-Guang Zhou

Jian-Kun Hu

Affiliations

Soon will be listed here.

Abstract

Background: To study metastasis to the infra-pyloric (no. 6) lymph nodes and their subgroups and the related risk factors of gastric cancer patients.

Methods: Gastric cancer patients who underwent gastrectomy with complete postoperative pathological information on the no. 6 lymph node station and its subgroups from January 1, 2008, to December 31, 2011, were included. The clinicopathological characteristics and survival outcomes were analyzed.

Results: A total of 121 patients were included; they had 6.1 ± 7.7 positive lymph nodes, and 35.1 ± 14.2 lymph nodes were examined. The overall lymph node positivity rate was 67.8% (82/121) with a positivity rate of 28.1% (34/121) for the no. 6 lymph nodes. The metastasis rate was 6.6% for the no. 6a nodes, 6.6% for the no. 6b nodes, and 21.5% for the no. 6c nodes. Also, no. 8a (OR = 1.329, p = 0.017) and no. 9 (OR = 1.250, p = 0.022) nodal positivity and lower third tumor location (OR = 1.278, p = 0.001) were independent risk factors for no. 6 lymph nodal metastasis. There was a significant survival difference between patients with positive and negative no. 6 lymph nodes and patients with metastasis to other lymph node stations (p < 0.001).

Conclusions: Patients with no. 6 lymph node metastasis have poor survival outcomes. Complete infra-pyloric lymphadenectomy is necessary and crucial for gastric cancer patients.

Citing Articles

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Prognostic Score System Using Preoperative Inflammatory, Nutritional and Tumor Markers to Predict Prognosis for Gastric Cancer: A Two-Center Cohort Study.

Pang H, Zhang W, Liang X, Zhang Z, Chen X, Zhao L Adv Ther. 2021; 38(9):4917-4934.

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Laparoscopic infrapyloric lymph nodes dissection through the right bursa omentalis approach for gastric cancer.

Yang K, Zhang W, Liu K, Chen X, Chen X, Zhou Z BMC Surg. 2021; 21(1):216.

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Pan G, Ma Y, Suo J, Li W, Zhang Y, Qin S Onco Targets Ther. 2020; 13:7199-7211.

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