Low Gestational Age at Birth and Difficulties in School-A Matter of 'dose'

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Jun 21

PMID 29924838

Citations 4

Authors

Rikke Wiingreen

Gorm Greisen

Jannet Svensson

Bo Molholm Hansen

Affiliations

Soon will be listed here.

Abstract

Objectives: Several studies suggest a relationship between gestational age at birth and risk of school difficulties. Our study aimed to investigate the association between the entire range of gestational ages and significant school difficulties measured as 1) More than nine hours per week special educational support and 2) Failing to complete compulsory school.

Methods: A population-based register study including all children attending the Danish compulsory school in 2015/2016 and all live-born infants born in Denmark from 1992 to 1997. Data were collected and linked using multiple registers held by Statistic Denmark. Multiple logistic regression analyses were used to estimate the association between gestational age and significant school difficulties, adjusted for explanatory variables.

Results: For measurement 1) "Special educational support" 615,789 children entered the analyses after exclusion of those with missing neonatal data. The risk of special educational support increased gradually across the entire range of gestation from 40 to ≤24 weeks: The adjusted odds ratio was 1.07 (95% confidence interval 1.03-1.12) at 39 weeks of gestational and 6.18 (95% confidence interval 5.17-7.39) at gestational ages < 28 weeks. For measurement 2) "Failing to complete compulsory school" the cohort consisted of 374,798 children after exclusion of those who died, had emigrated and/or had missing neonatal data. The risk of failing to complete compulsory school increased across the entire range of gestational ages: The adjusted odds ratio was 1.07 (95% confidence interval 1.04-1.10) at 39 weeks of gestation and 2.99 (95% confidence interval 2.41-3.71) at gestational ages < 28 weeks. In both sets of analyses GA = 40 weeks was used as reference.

Conclusions: We confirm a clear association between the degree of prematurity and significant school difficulties across the entire range of gestational ages from ≤ 24 to 40 weeks.

Citing Articles

Cognitive and academic outcomes of large-for-gestational-age babies born at early term: A systematic review and meta-analysis.

Zhao X, Poskett A, Stracke M, Quenby S, Wolke D Acta Obstet Gynecol Scand. 2024; 104(2):288-301.

PMID: 39475202 PMC: 11782071. DOI: 10.1111/aogs.15001.

Offspring school performance at age 12 after induction of labor vs non-intervention at term: A linked cohort study.

Burger R, Mol B, Ganzevoort W, Gordijn S, Pajkrt E, van der Post J Acta Obstet Gynecol Scand. 2023; 102(4):486-495.

PMID: 36810769 PMC: 10008265. DOI: 10.1111/aogs.14520.

Socioeconomic outcomes beyond 30 years of age in a cohort born with very low birth weight.

Kure Pollstergaard K, Wiingreen R, Gregersen R, Mathiasen R, Molholm Hansen B, Greisen G Acta Paediatr. 2022; 112(1):78-84.

PMID: 36176205 PMC: 10091976. DOI: 10.1111/apa.16557.

Association of Gestational Age at Birth With Subsequent Neurodevelopment in Early Childhood: A National Retrospective Cohort Study in China.

Hua J, Barnett A, Lin Y, Guan H, Sun Y, Williams G Front Pediatr. 2022; 10:860192.

PMID: 35712637 PMC: 9194570. DOI: 10.3389/fped.2022.860192.

Gestational Age at Term and Educational Outcomes at Age Nine.

Hedges A, Corman H, Noonan K, Reichman N Pediatrics. 2021; 148(2).

PMID: 34244451 PMC: 8344335. DOI: 10.1542/peds.2020-021287.

References

Marsal K, Persson P, Larsen T, Lilja H, Selbing A, Sultan B . Intrauterine growth curves based on ultrasonically estimated foetal weights. Acta Paediatr. 1996; 85(7):843-8. DOI: 10.1111/j.1651-2227.1996.tb14164.x. View

Mathiasen R, Hansen B, Andersen A, Forman J, Greisen G . Gestational age and basic school achievements: a national follow-up study in Denmark. Pediatrics. 2010; 126(6):e1553-61. DOI: 10.1542/peds.2009-0829. View

Ahlsson F, Kaijser M, Adami J, Lundgren M, Palme M . School performance after preterm birth. Epidemiology. 2014; 26(1):106-11. DOI: 10.1097/EDE.0000000000000171. View

Chyi L, Lee H, Hintz S, Gould J, Sutcliffe T . School outcomes of late preterm infants: special needs and challenges for infants born at 32 to 36 weeks gestation. J Pediatr. 2008; 153(1):25-31. DOI: 10.1016/j.jpeds.2008.01.027. View

Noble K, Fifer W, Rauh V, Nomura Y, Andrews H . Academic achievement varies with gestational age among children born at term. Pediatrics. 2012; 130(2):e257-64. PMC: 3408682. DOI: 10.1542/peds.2011-2157. View

Mathiasen R, Hansen B, Nybo Anderson A, Greisen G . Socio-economic achievements of individuals born very preterm at the age of 27 to 29 years: a nationwide cohort study. Dev Med Child Neurol. 2009; 51(11):901-8. DOI: 10.1111/j.1469-8749.2009.03331.x. View

Bhutta A, Cleves M, Casey P, Cradock M, Anand K . Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA. 2002; 288(6):728-37. DOI: 10.1001/jama.288.6.728. View

Mackay D, Smith G, Dobbie R, Pell J . Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren. PLoS Med. 2010; 7(6):e1000289. PMC: 2882432. DOI: 10.1371/journal.pmed.1000289. View

Yang S, Platt R, Kramer M . Variation in child cognitive ability by week of gestation among healthy term births. Am J Epidemiol. 2010; 171(4):399-406. PMC: 3435092. DOI: 10.1093/aje/kwp413. View

10.

Walsh J, Doyle L, Anderson P, Lee K, Cheong J . Moderate and late preterm birth: effect on brain size and maturation at term-equivalent age. Radiology. 2014; 273(1):232-40. DOI: 10.1148/radiol.14132410. View

11.

Talge N, Holzman C, Wang J, Lucia V, Gardiner J, Breslau N . Late-preterm birth and its association with cognitive and socioemotional outcomes at 6 years of age. Pediatrics. 2010; 126(6):1124-31. DOI: 10.1542/peds.2010-1536. View

12.

Lipkind H, Slopen M, Pfeiffer M, McVeigh K . School-age outcomes of late preterm infants in New York City. Am J Obstet Gynecol. 2012; 206(3):222.e1-6. DOI: 10.1016/j.ajog.2012.01.007. View

13.

Schmidt M, Pedersen L, Sorensen H . The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol. 2014; 29(8):541-9. DOI: 10.1007/s10654-014-9930-3. View

14.

Moster D, Lie R, Markestad T . Long-term medical and social consequences of preterm birth. N Engl J Med. 2008; 359(3):262-73. DOI: 10.1056/NEJMoa0706475. View

15.

Aarnoudse-Moens C, Weisglas-Kuperus N, van Goudoever J, Oosterlaan J . Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics. 2009; 124(2):717-28. DOI: 10.1542/peds.2008-2816. View

16.

Gill J, Boyle E . Outcomes of infants born near term. Arch Dis Child. 2016; 102(2):194-198. DOI: 10.1136/archdischild-2015-309584. View

17.

Chan E, Leong P, Malouf R, Quigley M . Long-term cognitive and school outcomes of late-preterm and early-term births: a systematic review. Child Care Health Dev. 2016; 42(3):297-312. DOI: 10.1111/cch.12320. View

18.

Poulsen G, Wolke D, Kurinczuk J, Boyle E, Field D, Alfirevic Z . Gestational age and cognitive ability in early childhood: a population-based cohort study. Paediatr Perinat Epidemiol. 2013; 27(4):371-9. DOI: 10.1111/ppe.12058. View

19.

Johnson S, Hennessy E, Smith R, Trikic R, Wolke D, Marlow N . Academic attainment and special educational needs in extremely preterm children at 11 years of age: the EPICure study. Arch Dis Child Fetal Neonatal Ed. 2009; 94(4):F283-9. DOI: 10.1136/adc.2008.152793. View

20.

Quigley M, Poulsen G, Boyle E, Wolke D, Field D, Alfirevic Z . Early term and late preterm birth are associated with poorer school performance at age 5 years: a cohort study. Arch Dis Child Fetal Neonatal Ed. 2012; 97(3):F167-73. DOI: 10.1136/archdischild-2011-300888. View