Metabolic Syndrome in Adults with a History of Juvenile Arthritis

Overview

Journal Open Access Rheumatol

Publisher Dove Medical Press

Specialty Rheumatology

Date 2018 Jun 21

PMID 29922101

Citations 5

Authors

Sangeeta Sule

Kevin Fontaine

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to determine the risk of obesity and metabolic syndrome in adults with a history of juvenile arthritis (JA).

Methods: Using the National Health and Nutrition Examination Survey (NHANES), we compared the characteristics of respondents with arthritis (JA vs rheumatoid arthritis [RA]) to those of the control group without arthritis. We used logistic regression analyses, controlling for age, race, and gender, to determine the ORs for metabolic syndrome.

Results: Obesity was increased in the JA group with 67% respondents having body mass index ≥30 kg/m vs 55% respondents in the no arthritis cohort (=0.004). In unadjusted analyses, there was increased odds of metabolic syndrome in JA (OR 6.2, =0.001) and RA groups compared to those without arthritis (OR 7.7, =0.001). After adjusting for age, gender, and race, the odds of metabolic syndrome remained increased in JA (OR 5.2, =0.001) and RA (OR 3.2, =0.001) groups.

Conclusion: Adults with a history of JA have a significantly increased risk of metabolic syndrome compared to those without arthritis. These findings are important because metabolic syndrome has been associated with an increased risk of cardiovascular disease and death in other populations.

Citing Articles

Exploring nutritional risks of the specific carbohydrate diet: food and nutrient intake in children with juvenile idiopathic arthritis.

Hagstrom N, Koochek A, Warensjo Lemming E, Oman A, Arnell H, Berntson L J Nutr Sci. 2025; 14:e9.

PMID: 39943929 PMC: 11811854. DOI: 10.1017/jns.2024.92.

Association between dietary inflammatory index and all-cause mortality in patients with osteopenia or osteoporosis: A retrospective cohort study from the NHANES 2007-2018.

Ke C, Zhang X, Wang X Prev Med Rep. 2024; 45:102826.

PMID: 39156725 PMC: 11328027. DOI: 10.1016/j.pmedr.2024.102826.

The dual role of body mass index on Juvenile Idiopathic Arthritis course: a pediatric experience.

Gicchino M, Marzuillo P, Melone R, Zarrilli S, Del Giudice E, Olivieri A Eur J Pediatr. 2023; 183(2):809-813.

PMID: 38015262 DOI: 10.1007/s00431-023-05348-8.

Adipose tissue distribution is associated with cardio-metabolic alterations in adult patients with juvenile-onset dermatomyositis.

Marstein H, Witczak B, Godang K, Schwartz T, Flato B, Bollerslev J Rheumatology (Oxford). 2022; 62(SI2):SI196-SI204.

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Recent Updates in Juvenile Spondyloarthritis.

Srinivasalu H, Sikora K, Colbert R Rheum Dis Clin North Am. 2021; 47(4):565-583.

PMID: 34635292 PMC: 8511508. DOI: 10.1016/j.rdc.2021.07.001.

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