Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Jun 21

PMID 29921817

Citations 10

Authors

Wei Shi

Hongkuan Deng

Jianyong Zhang

Ying Zhang

Xiufang Zhang

Guozhen Cui

Affiliations

Soon will be listed here.

Abstract

Doxorubicin (Dox) is a chemotherapeutic agent widely used for the treatment of numerous cancers. However, the clinical use of Dox is limited by its unwanted cardiotoxicity. Mitochondrial dysfunction has been associated with Dox-induced cardiotoxicity. To mitigate Dox-related cardiotoxicity, considerable successful examples of a variety of small molecules that target mitochondria to modulate Dox-induced cardiotoxicity have appeared in recent years. Here, we review the related literatures and discuss the evidence showing that mitochondria-targeting small molecules are promising cardioprotective agents against Dox-induced cardiac events.

Citing Articles

Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity.

Pal C Cardiovasc Toxicol. 2024; 25(2):216-247.

PMID: 39495464 DOI: 10.1007/s12012-024-09941-7.

Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes.

Tang X, Liu H, Rao R, Huang Y, Dong M, Xu M Sci China Life Sci. 2023; 67(2):301-319.

PMID: 37864082 DOI: 10.1007/s11427-023-2369-3.

Multiple mitochondria-targeted components screened from Sini decoction improved cardiac energetics and mitochondrial dysfunction to attenuate doxorubicin-induced cardiomyopathy.

Ding X, Zhang Y, Pan P, Long C, Zhang X, Zhuo L Theranostics. 2023; 13(2):510-530.

PMID: 36632225 PMC: 9830424. DOI: 10.7150/thno.80066.

Mitochondrial-Targeted Therapy for Doxorubicin-Induced Cardiotoxicity.

Wu B, Leung K, Poon E Int J Mol Sci. 2022; 23(3).

PMID: 35163838 PMC: 8837080. DOI: 10.3390/ijms23031912.

Lapatinib induces mitochondrial dysfunction to enhance oxidative stress and ferroptosis in doxorubicin-induced cardiomyocytes via inhibition of PI3K/AKT signaling pathway.

Sun L, Wang H, Xu D, Yu S, Zhang L, Li X Bioengineered. 2021; 13(1):48-60.

PMID: 34898356 PMC: 8805895. DOI: 10.1080/21655979.2021.2004980.

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