Exposure to Hypoglycemia and Risk of Stroke

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2018 Jun 20

PMID 29917249

Citations 15

Authors

Logan Smith

Diya Chakraborty

Pallab Bhattacharya

Deepaneeta Sarmah

Sebastian Koch

Kunjan R Dave

Affiliations

Soon will be listed here.

Abstract

In the treatment of both type 1 and type 2 diabetes mellitus, maintaining a euglycemic state represents one of the key challenges. Improper dosing and administration of glucose-lowering drugs is associated with an increased risk of recurrent hypoglycemia episodes. In addition, the risk of adverse cardiovascular events in diabetic patients, particularly myocardial infarctions and strokes, is well established. Current research indicates a potential link between the baseline risk of cardio/cerebrovascular events in diabetic patients and exposure to hypoglycemia. In this review of the literature, we aim to determine if a relationship exists between recurrent hypoglycemia and adverse neurovascular events.

Citing Articles

The fuzzy MAD stroke conjecture, using Fuzzy C Means to classify multimodal apparent diffusion for ischemic stroke lesion stratification.

Damen F, Su C, Tsuruda J, Anderson T, Valyi-Nagy T, Li W Magn Reson Imaging. 2024; 117:110294.

PMID: 39638136 PMC: 11807747. DOI: 10.1016/j.mri.2024.110294.

Relationship between glycated hemoglobin levels and three-month outcomes in acute ischemic stroke patients with or without diabetes: a prospective Korean cohort study.

Cao C, Wang T, Hu H, Han Y, Zhang X, Wang Y BMC Neurol. 2024; 24(1):85.

PMID: 38433248 PMC: 10910674. DOI: 10.1186/s12883-024-03581-8.

Predicting short-term outcomes in atrial-fibrillation-related stroke using machine learning.

Jeon E, Jung S, Yeo T, Seo W, Jung J Front Neurol. 2023; 14:1243700.

PMID: 38020627 PMC: 10663332. DOI: 10.3389/fneur.2023.1243700.

Acute severe hypoglycemia alters mouse brain microvascular proteome.

Sakamuri S, Sure V, Oruganti L, Wisen W, Chandra P, Liu N J Cereb Blood Flow Metab. 2023; 44(4):556-572.

PMID: 37944245 PMC: 10981402. DOI: 10.1177/0271678X231212961.

The Prognostic Significance of Early Glycemic Profile in Acute Ischemic Stroke Depends on Stroke Subtype.

Forti P, Maioli F J Clin Med. 2023; 12(5).

PMID: 36902581 PMC: 10003561. DOI: 10.3390/jcm12051794.

References

Gitt A, Bramlage P, Binz C, Krekler M, Deeg E, Tschope D . Prognostic implications of DPP-4 inhibitor vs. sulfonylurea use on top of metformin in a real world setting - results of the 1 year follow-up of the prospective DiaRegis registry. Int J Clin Pract. 2013; 67(10):1005-14. DOI: 10.1111/ijcp.12179. View

Lee A, Warren B, Lee C, McEvoy J, Matsushita K, Huang E . The Association of Severe Hypoglycemia With Incident Cardiovascular Events and Mortality in Adults With Type 2 Diabetes. Diabetes Care. 2017; 41(1):104-111. PMC: 5741158. DOI: 10.2337/dc17-1669. View

Cherian P, Hankey G, Eikelboom J, Thom J, Baker R, McQuillan A . Endothelial and platelet activation in acute ischemic stroke and its etiological subtypes. Stroke. 2003; 34(9):2132-7. DOI: 10.1161/01.STR.0000086466.32421.F4. View

Zharikov S, Shiva S . Platelet mitochondrial function: from regulation of thrombosis to biomarker of disease. Biochem Soc Trans. 2013; 41(1):118-23. DOI: 10.1042/BST20120327. View

Joy N, Tate D, Younk L, Davis S . Effects of Acute and Antecedent Hypoglycemia on Endothelial Function and Markers of Atherothrombotic Balance in Healthy Humans. Diabetes. 2015; 64(7):2571-80. PMC: 4477350. DOI: 10.2337/db14-1729. View

. Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia. 2007; 50(6):1140-7. DOI: 10.1007/s00125-007-0599-y. View

Suh S, Hamby A, Gum E, Shin B, Won S, Sheline C . Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death. J Cereb Blood Flow Metab. 2008; 28(10):1697-706. DOI: 10.1038/jcbfm.2008.61. View

Khunti K, Alsifri S, Aronson R, Cigrovski Berkovic M, Enters-Weijnen C, Forsen T . Rates and predictors of hypoglycaemia in 27 585 people from 24 countries with insulin-treated type 1 and type 2 diabetes: the global HAT study. Diabetes Obes Metab. 2016; 18(9):907-15. PMC: 5031206. DOI: 10.1111/dom.12689. View

Freynhofer M, Bruno V, Wojta J, Huber K . The role of platelets in athero-thrombotic events. Curr Pharm Des. 2012; 18(33):5197-214. DOI: 10.2174/138161212803251899. View

10.

Altes A, Abellan M, Mateo J, Avila A, Marti-Vilalta J, Fontcuberta J . Hemostatic disturbances in acute ischemic stroke: a study of 86 patients. Acta Haematol. 1995; 94(1):10-5. DOI: 10.1159/000203964. View

11.

Isaev N, Stelmashook E, Dirnagl U, Plotnikov E, Kuvshinova E, Zorov D . Mitochondrial free radical production induced by glucose deprivation in cerebellar granule neurons. Biochemistry (Mosc). 2008; 73(2):149-55. DOI: 10.1134/s0006297908020053. View

12.

Fisher B, Quin J, Rumley A, Lennie S, Small M, MacCuish A . Effects of acute insulin-induced hypoglycaemia on haemostasis, fibrinolysis and haemorheology in insulin-dependent diabetic patients and control subjects. Clin Sci (Lond). 1991; 80(5):525-31. DOI: 10.1042/cs0800525. View

13.

. Nine-Year Effects of 3.7 Years of Intensive Glycemic Control on Cardiovascular Outcomes. Diabetes Care. 2016; 39(5):701-8. PMC: 4839177. DOI: 10.2337/dc15-2283. View

14.

Hartley P, Savill J, Brown S . Hypoglycaemia predisposes platelets to death by affecting calcium homeostasis and mitochondrial integrity. Platelets. 2007; 18(2):103-12. DOI: 10.1080/09537100600760822. View

15.

Donnelly L, Morris A, Frier B, Ellis J, Donnan P, Durrant R . Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study. Diabet Med. 2005; 22(6):749-55. DOI: 10.1111/j.1464-5491.2005.01501.x. View

16.

Heller S, Amiel S, Khunti K . Hypoglycaemia, a global cause for concern. Diabetes Res Clin Pract. 2015; 110(2):229-32. DOI: 10.1016/j.diabres.2015.11.004. View

17.

Gehlaut R, Dogbey G, Schwartz F, Marling C, Shubrook J . Hypoglycemia in Type 2 Diabetes--More Common Than You Think: A Continuous Glucose Monitoring Study. J Diabetes Sci Technol. 2015; 9(5):999-1005. PMC: 4667336. DOI: 10.1177/1932296815581052. View

18.

Tohgi H, Konno S, Takahashi S, Koizumi D, Kondo R, Takahashi H . Activated coagulation/fibrinolysis system and platelet function in acute thrombotic stroke patients with increased C-reactive protein levels. Thromb Res. 2001; 100(5):373-9. DOI: 10.1016/s0049-3848(00)00356-x. View

19.

Papanas N, Maltezos E . Oral antidiabetic agents: anti-atherosclerotic properties beyond glucose lowering?. Curr Pharm Des. 2009; 15(27):3179-92. DOI: 10.2174/138161209789057995. View

20.

Rathmann W, Kostev K, Gruenberger J, Dworak M, Bader G, Giani G . Treatment persistence, hypoglycaemia and clinical outcomes in type 2 diabetes patients with dipeptidyl peptidase-4 inhibitors and sulphonylureas: a primary care database analysis. Diabetes Obes Metab. 2012; 15(1):55-61. DOI: 10.1111/j.1463-1326.2012.01674.x. View