Shining Light on Chitosan: A Review on the Usage of Chitosan for Photonics and Nanomaterials Research

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Jun 20

PMID 29914214

Citations 14

Authors

Sreekar B Marpu

Erin N Benton

Affiliations

Soon will be listed here.

Abstract

Chitosan (CS) is a natural polymer derived from chitin that has found its usage both in research and commercial applications due to its unique solubility and chemical and biological attributes. The biocompatibility and biodegradability of CS have helped researchers identify its utility in the delivery of therapeutic agents, tissue engineering, wound healing, and more. Industrial applications include cosmetic and personal care products, wastewater treatment, and corrosion protection, to name a few. Many researchers have published numerous reviews outlining the physical and chemical properties of CS, as well as its use for many of the above-mentioned applications. Recently, the cationic polyelectrolyte nature of CS was found to be advantageous for stabilizing fascinating photonic materials including plasmonic nanoparticles (e.g., gold and silver), semiconductor nanoparticles (e.g., zinc oxide, cadmium sulfide), fluorescent organic dyes (e.g., fluorescein isothiocyanate (FITC)), luminescent transitional and lanthanide complexes (e.g., Au(I) and Ru(II), and Eu(III)). These photonic systems have been extensively investigated for their usage in antimicrobial, wound healing, diagnostics, sensing, and imaging applications. Highlighted in this review are the different works involving some of the above-mentioned molecular-nano systems that are prepared or stabilized using the CS polymer. The advantages and the role of the CS for synthesizing and stabilizing the above-mentioned optically active materials have been illustrated.

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References

Yang Y, Cui J, Zheng M, Hu C, Tan S, Xiao Y . One-step synthesis of amino-functionalized fluorescent carbon nanoparticles by hydrothermal carbonization of chitosan. Chem Commun (Camb). 2011; 48(3):380-2. DOI: 10.1039/c1cc15678k. View

Bhatnagar A, Sillanpaa M . Applications of chitin- and chitosan-derivatives for the detoxification of water and wastewater--a short review. Adv Colloid Interface Sci. 2009; 152(1-2):26-38. DOI: 10.1016/j.cis.2009.09.003. View

Asghari F, Samiei M, Adibkia K, Akbarzadeh A, Davaran S . Biodegradable and biocompatible polymers for tissue engineering application: a review. Artif Cells Nanomed Biotechnol. 2016; 45(2):185-192. DOI: 10.3109/21691401.2016.1146731. View

Uehara N . Polymer-functionalized gold nanoparticles as versatile sensing materials. Anal Sci. 2010; 26(12):1219-28. DOI: 10.2116/analsci.26.1219. View

Sur I, Cam D, Kahraman M, Baysal A, Culha M . Interaction of multi-functional silver nanoparticles with living cells. Nanotechnology. 2010; 21(17):175104. DOI: 10.1088/0957-4484/21/17/175104. View

Jarmila V, Vavrikova E . Chitosan derivatives with antimicrobial, antitumour and antioxidant activities--a review. Curr Pharm Des. 2011; 17(32):3596-607. DOI: 10.2174/138161211798194468. View

Kong M, Chen X, Xing K, Park H . Antimicrobial properties of chitosan and mode of action: a state of the art review. Int J Food Microbiol. 2010; 144(1):51-63. DOI: 10.1016/j.ijfoodmicro.2010.09.012. View

Song X, Wu H, Li S, Wang Y, Ma X, Tan M . Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice. Biomacromolecules. 2015; 16(7):2080-90. DOI: 10.1021/acs.biomac.5b00511. View

Kim D, Park S, Lee J, Jeong Y, Jon S . Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J Am Chem Soc. 2007; 129(24):7661-5. DOI: 10.1021/ja071471p. View

10.

Ge L, Li Q, Wang M, Ouyang J, Li X, Xing M . Nanosilver particles in medical applications: synthesis, performance, and toxicity. Int J Nanomedicine. 2014; 9:2399-407. PMC: 4037247. DOI: 10.2147/IJN.S55015. View

11.

Aslan K, Lakowicz J, Geddes C . Metal-enhanced fluorescence using anisotropic silver nanostructures: critical progress to date. Anal Bioanal Chem. 2005; 382(4):926-33. PMC: 6844248. DOI: 10.1007/s00216-005-3195-3. View

12.

Tallury P, Kar S, Bamrungsap S, Huang Y, Tan W, Santra S . Ultra-small water-dispersible fluorescent chitosan nanoparticles: synthesis, characterization and specific targeting. Chem Commun (Camb). 2009; (17):2347-9. DOI: 10.1039/b901729a. View

13.

Wang H, Mukherjee S, Yi J, Banerjee P, Chen Q, Zhou S . Biocompatible Chitosan-Carbon Dot Hybrid Nanogels for NIR-Imaging-Guided Synergistic Photothermal-Chemo Therapy. ACS Appl Mater Interfaces. 2017; 9(22):18639-18649. DOI: 10.1021/acsami.7b06062. View

14.

No H, Meyers S, Prinyawiwatkul W, Xu Z . Applications of chitosan for improvement of quality and shelf life of foods: a review. J Food Sci. 2007; 72(5):R87-100. DOI: 10.1111/j.1750-3841.2007.00383.x. View

15.

Lucky S, Soo K, Zhang Y . Nanoparticles in photodynamic therapy. Chem Rev. 2015; 115(4):1990-2042. DOI: 10.1021/cr5004198. View

16.

Chakraborty I, Jimenez J, Mascharak P . CO-Induced apoptotic death of colorectal cancer cells by a luminescent photoCORM grafted on biocompatible carboxymethyl chitosan. Chem Commun (Camb). 2017; 53(40):5519-5522. PMC: 5728991. DOI: 10.1039/c7cc02842c. View

17.

Xing R, Yu H, Liu S, Zhang W, Zhang Q, Li Z . Antioxidant activity of differently regioselective chitosan sulfates in vitro. Bioorg Med Chem. 2005; 13(4):1387-92. DOI: 10.1016/j.bmc.2004.11.002. View

18.

Berger J, Reist M, Mayer J, Felt O, Gurny R . Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications. Eur J Pharm Biopharm. 2004; 57(1):35-52. DOI: 10.1016/s0939-6411(03)00160-7. View

19.

Jain A, Gulbake A, Shilpi S, Jain A, Hurkat P, Jain S . A new horizon in modifications of chitosan: syntheses and applications. Crit Rev Ther Drug Carrier Syst. 2013; 30(2):91-181. DOI: 10.1615/critrevtherdrugcarriersyst.2013005678. View

20.

Haider Naqvi S, Kiran U, Ali M, Jamal A, Hameed A, Ahmed S . Combined efficacy of biologically synthesized silver nanoparticles and different antibiotics against multidrug-resistant bacteria. Int J Nanomedicine. 2013; 8:3187-95. PMC: 3754765. DOI: 10.2147/IJN.S49284. View