Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2018 Jun 19

PMID 29912352

Citations 27

Authors

Zhilei Shan

Clary B Clish

Simin Hua

Justin M Scott

David B Hanna

Robert D Burk

Sabina A Haberlen

Sanjiv J Shah

Joseph B Margolick

Cynthia L Sears

Wendy S Post

Alan L Landay

Jason M Lazar

Howard N Hodis

Kathryn Anastos

Robert C Kaplan

Qibin Qi

Affiliations

Soon will be listed here.

Abstract

We examined associations of 5 plasma choline metabolites with carotid plaque among 520 HIV-infected and 217 HIV-uninfected participants (112 incident plaque cases) over 7 years. After multivariable adjustment, higher gut microbiota-related metabolite trimethylamine-N-oxide (TMAO) was associated with an increased risk of carotid plaque in HIV-infected participants (risk ratio = 1.25 per standard deviation increment; 95% confidence interval, 1.05-1.50; P = .01). TMAO was positively correlated with biomarkers of monocyte activation and inflammation (sCD14, sCD163). Further adjustment for these biomarkers attenuated the association between TMAO and carotid plaque (P = .08). Among HIV-infected individuals, plasma TMAO was associated with carotid atherosclerosis progression, partially through immune activation and inflammation.

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