Fetal Skeletal Size and Growth Are Relevant Biometric Markers in Vitamin D Deficient Mothers: A North East India Prospective Cohort Study

Overview

Journal Indian J Endocrinol Metab

Specialty Endocrinology

Date 2018 Jun 19

PMID 29911034

Citations 5

Authors

Dipti Sarma

Uma K Saikia

Darvin V Das

Affiliations

Soon will be listed here.

Abstract

Context: The neonatal skeletal outcomes due to maternal Vitamin D deficiency.

Aims: The aim of this study is to assess the serum 25 hydroxy Vitamin D (25[OH]D) status in pregnant women and correlate with cord blood 25(OH)D levels, femur length at 34 weeks gestation, and neonatal anthropometry (birth weight, birth length, and head circumference).

Settings And Design: This was prospective cohort study.

Subjects And Methods: This study was carried out in 250 healthy primigravida between 18 and 40 years of age in the third trimester of gestation attending the Obstetrics and Gynaecology Department of Gauhati Medical College, Guwahati from December 2012 to December 2015. Dietary assessment of calcium and Vitamin D intake, sunlight exposure among the pregnant mothers and fetal femur length measurements were done. The neonates were followed up at birth for biometric assessment and the estimation of cord 25(OH)D.

Statistical Analysis Used: Chi-square test and Pearson correlation were carried out to see the association and correlation between different variables. Statistical significance was set at the 0.05 level.

Results: We found low Vitamin D levels (60%) in the majority of pregnant mothers and newborns (62.4%). The mean Vitamin D levels were 17.51 ± 2.24 ng/ml and 14.51 ± 1.8 ng/ml among the low Vitamin D maternal subjects and their new born, respectively. There was a significant association of maternal Vitamin D levels with sun exposure, dietary intake of Vitamin D, serum calcium, serum alkaline phosphatase levels, and serum parathyroid hormone in subjects with low Vitamin D. Fetal femur length and birth length were significantly shorter in mothers with low Vitamin D ( < 0.01).

Conclusions: Maternal hypovitaminosis D was associated with adverse skeletal outcome in neonates.

Citing Articles

Maternal vitamin D status, fetal growth patterns, and adverse pregnancy outcomes in a multisite prospective pregnancy cohort.

Beck C, Blue N, Silver R, Na M, Grobman W, Steller J Am J Clin Nutr. 2024; 121(2):376-384.

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Impact of vitamin D on maternal and fetal health: A review.

Arshad R, Sameen A, Murtaza M, Sharif H, Iahtisham-Ul-Haq , Dawood S Food Sci Nutr. 2022; 10(10):3230-3240.

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Maternal vitamin D and growth of under-five children: a systematic review and meta-analysis of observational and interventional studies.

Tareke A, Alem A, Debebe W, Bayileyegn N, Abebe M, Abdu H Glob Health Action. 2022; 15(1):2102712.

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The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review.

Dimas A, Politi A, Bargiota A, Panoskaltsis T, Vlahos N, Valsamakis G Int J Mol Sci. 2022; 23(15).

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Editorial: Classic and Pleiotropic Actions of Vitamin D.

Pludowski P, Grant W, Konstantynowicz J, Holick M Front Endocrinol (Lausanne). 2019; 10:341.

PMID: 31191460 PMC: 6549583. DOI: 10.3389/fendo.2019.00341.

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