Current and Emerging Therapies for Corneal Neovascularization

Overview

Journal Ocul Surf

Specialty Ophthalmology

Date 2018 Jun 18

PMID 29908870

Citations 68

Authors

Danial Roshandel

Medi Eslani

Alireza Baradaran-Rafii

Albert Y Cheung

Khaliq Kurji

Sayena Jabbehdari

Alejandra Maiz

Setareh Jalali

Ali R Djalilian

Edward J Holland

Affiliations

Soon will be listed here.

Abstract

The cornea is unique because of its complete avascularity. Corneal neovascularization (CNV) can result from a variety of etiologies including contact lens wear; corneal infections; and ocular surface diseases due to inflammation, chemical injury, and limbal stem cell deficiency. Management is focused primarily on the etiology and pathophysiology causing the CNV and involves medical and surgical options. Because inflammation is a key factor in the pathophysiology of CNV, corticosteroids and other anti-inflammatory medications remain the mainstay of treatment. Anti-VEGF therapies are gaining popularity to prevent CNV in a number of etiologies. Surgical options including vessel occlusion and ocular surface reconstruction are other options depending on etiology and response to medical therapy. Future therapies should provide more effective treatment options for the management of CNV.

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