Atypical Cutaneous Presentations of Sarcoidosis: Two Case Reports and Review of the Literature

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2018 Jun 16

PMID 29904803

Citations 3

Authors

David L Leverenz

Christopher Henderson

Ankoor Shah

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The goal of this review is to provide the reader with an updated summary of the cutaneous manifestations of systemic sarcoidosis, with a particular emphasis on the predilection of sarcoidosis for scars, tattoos, and other areas of traumatized skin.

Recent Findings: While the mechanism underlying the propensity for traumatized skin to develop sarcoidosis lesions remains unclear, several theories have been proposed including the idea that cutaneous sarcoidosis represents an exuberant, antigen-driven foreign-body response, as well as the theory that traumatized skin represents an immunocompromised district with altered local immune trafficking and neural signaling. In this review, we present two cases in which the development of cutaneous lesions in scars and tattoos was integral to the diagnosis of systemic sarcoidosis. We then review the various cutaneous manifestations of systemic sarcoidosis, the clinical characteristics and differential diagnosis of scar and tattoo sarcoidosis, the proposed mechanism by which traumatized skin is prone to developing sarcoidosis lesions, and current treatments for cutaneous sarcoidosis.

Citing Articles

Skin Sarcoidosis on Both Vitiligo and Tattoos in the Same Patient: Report of an Exceptional Case and Pathogenetic Hypotheses of Intriguing Associations.

Corazza M, Schettini N, Forconi R, Ferron P, Leprotti S, Borghi A Indian J Dermatol. 2022; 66(5):565-566.

PMID: 35068521 PMC: 8751711. DOI: 10.4103/ijd.ijd_884_20.

Tattoo-Associated Sarcoidosis With Severe Uveitis Successfully Treated With Mycophenolate Mofetil: A Report of Two Cases.

Nso N, Toz B, Ching T, Kondaveeti R, Abrudescu A Cureus. 2021; 13(8):e17197.

PMID: 34540425 PMC: 8439406. DOI: 10.7759/cureus.17197.

Immunocompromised Districts of Skin: A Case Series and a Literature Review.

Vojvodic A, Tirant M, Di Nardo V, Lotti T, Wollina U Open Access Maced J Med Sci. 2019; 7(18):2969-2975.

PMID: 31850101 PMC: 6910813. DOI: 10.3889/oamjms.2019.680.

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