Increasing Incidence of Central Nervous System (CNS) Tumors (2000-2012): Findings from a Population Based Registry in Gironde (France)

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2018 Jun 15

PMID 29898691

Citations 20

Authors

Camille Pouchieu

Anne Gruber

Emilie Berteaud

Patrice Menegon

Pascal Monteil

Aymeri Huchet

Jean-Rodolphe Vignes

Anne Vital

Hugues Loiseau

Isabelle Baldi

Affiliations

Soon will be listed here.

Abstract

Background: Although some countries have observed a stabilization in the incidence of CNS, an increasing incidence has been reported from multiple studies. Recent observations point out to the heterogeneity of incidence trends according to histological subtypes, gender and age-groups. Using a high-quality regional CNS tumor registry, this article describes the trends of CNS tumor incidence for main histological subtypes, including benign and malignant tumors, in the French department of Gironde from 2000 to 2012.

Methods: Crude and age-standardized incidence rates were calculated globally, by histological subtypes, malignant status, gender and age groups. For trends, annual percent changes (APC) were obtained from a piecewise log-linear model.

Results: A total of 3515 CNS tumors was registered during the period. The incidence of overall CNS tumors was 19/100000 person-years (8.3/100000 for neuroepithelial tumors and 7.3/100000 for meningeal tumors). An increased incidence of overall CNS tumors was observed from 2000 to 2012 (APC = + 2.7%; 95%-confidence interval (CI): 1.8-3.7). This trend was mainly explained by an increase in the incidence of meningiomas over the period (APC = + 5.4%, 95%-CI: 3.8-7.0). The increased incidence rate of CNS tumors was more pronounced in female and in older patients even though the incidence rate increased in all age groups.

Conclusions: Part of the temporal variation may be attributed to improvement in registration, diagnosis and clinical practices but also to changes in potential risk factors. Thus, etiological studies on CNS tumors are needed to clarify this rising trend.

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References

Hess K, Broglio K, Bondy M . Adult glioma incidence trends in the United States, 1977-2000. Cancer. 2004; 101(10):2293-9. DOI: 10.1002/cncr.20621. View

Niedermaier T, Behrens G, Schmid D, Schlecht I, Fischer B, Leitzmann M . Body mass index, physical activity, and risk of adult meningioma and glioma: A meta-analysis. Neurology. 2015; 85(15):1342-50. DOI: 10.1212/WNL.0000000000002020. View

Deltour I, Johansen C, Auvinen A, Feychting M, Klaeboe L, Schuz J . Time trends in brain tumor incidence rates in Denmark, Finland, Norway, and Sweden, 1974-2003. J Natl Cancer Inst. 2009; 101(24):1721-4. DOI: 10.1093/jnci/djp415. View

Lannering B, Sandstrom P, Holm S, Lundgren J, Pfeifer S, Samuelsson U . Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984-2005. Acta Paediatr. 2009; 98(10):1620-7. DOI: 10.1111/j.1651-2227.2009.01417.x. View

DOLL R, Cook P . Summarizing indices for comparison of cancer incidence data. Int J Cancer. 1967; 2(3):269-79. DOI: 10.1002/ijc.2910020310. View

Christensen H, Kosteljanetz M, Johansen C . Incidences of gliomas and meningiomas in Denmark, 1943 to 1997. Neurosurgery. 2003; 52(6):1327-33; discussion 1333-4. DOI: 10.1227/01.neu.0000064802.46759.53. View

Caldarella A, Crocetti E, Paci E . Is the incidence of brain tumors really increasing? A population-based analysis from a cancer registry. J Neurooncol. 2011; 104(2):589-94. DOI: 10.1007/s11060-011-0533-5. View

Fuentes-Raspall R, Vilardell L, Perez-Bueno F, Joly C, Garcia-Gil M, Garcia-Velasco A . Population-based incidence and survival of central nervous system (CNS) malignancies in Girona (Spain) 1994-2005. J Neurooncol. 2010; 101(1):117-23. DOI: 10.1007/s11060-010-0240-7. View

Jukich P, McCarthy B, Surawicz T, Freels S, Davis F . Trends in incidence of primary brain tumors in the United States, 1985-1994. Neuro Oncol. 2001; 3(3):141-51. PMC: 1920618. DOI: 10.1093/neuonc/3.3.141. View

10.

. Non-ionizing radiation, Part 2: Radiofrequency electromagnetic fields. IARC Monogr Eval Carcinog Risks Hum. 2014; 102(Pt 2):1-460. PMC: 4780878. View

11.

Nomura E, Ioka A, Tsukuma H . Trends in the incidence of primary intracranial tumors in Osaka, Japan. Jpn J Clin Oncol. 2011; 41(2):291-4. DOI: 10.1093/jjco/hyq204. View

12.

Schmidt L, Schmiegelow K, Lahteenmaki P, Trager C, Stokland T, Grell K . Incidence of childhood central nervous system tumors in the Nordic countries. Pediatr Blood Cancer. 2010; 56(1):65-9. DOI: 10.1002/pbc.22585. View

13.

Dolecek T, Dressler E, Thakkar J, Liu M, Al-Qaisi A, Villano J . Epidemiology of meningiomas post-Public Law 107-206: The Benign Brain Tumor Cancer Registries Amendment Act. Cancer. 2015; 121(14):2400-10. PMC: 5549267. DOI: 10.1002/cncr.29379. View

14.

Ostrom Q, Gittleman H, Liao P, Rouse C, Chen Y, Dowling J . CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014; 16 Suppl 4:iv1-63. PMC: 4193675. DOI: 10.1093/neuonc/nou223. View

15.

Jung K, Ha J, Lee S, Won Y, Yoo H . An updated nationwide epidemiology of primary brain tumors in republic of Korea. Brain Tumor Res Treat. 2014; 1(1):16-23. PMC: 4027117. DOI: 10.14791/btrt.2013.1.1.16. View

16.

Gittleman H, Ostrom Q, Rouse C, Dowling J, de Blank P, Kruchko C . Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010. Cancer. 2014; 121(1):102-12. PMC: 4298242. DOI: 10.1002/cncr.29015. View

17.

Kim S, Ioannides S, Elwood J . Trends in incidence of primary brain cancer in New Zealand, 1995 to 2010. Aust N Z J Public Health. 2015; 39(2):148-52. DOI: 10.1111/1753-6405.12338. View

18.

Davis F, Malinski N, Haenszel W, Chang J, Flannery J, Gershman S . Primary brain tumor incidence rates in four United States regions, 1985-1989: a pilot study. Neuroepidemiology. 1996; 15(2):103-12. DOI: 10.1159/000109895. View

19.

Darefsky A, Dubrow R . International variation in the incidence of adult primary malignant neoplasms of the brain and central nervous system. Cancer Causes Control. 2009; 20(9):1593-604. DOI: 10.1007/s10552-009-9404-1. View

20.

McCarthy B, Kruchko C, Dolecek T . The impact of the Benign Brain Tumor Cancer Registries Amendment Act (Public Law 107-260) on non-malignant brain and central nervous system tumor incidence trends. J Registry Manag. 2013; 40(1):32-5. View