Use of Antihypertensive Drugs During Preeclampsia

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2018 Jun 14

PMID 29896480

Citations 21

Authors

Obinnaya Odigboegwu

Lu J Pan

Piyali Chatterjee

Affiliations

Soon will be listed here.

Abstract

Treatment of pregnancy-related hypertensive disorders, such as preeclampsia (PE), remain a challenging problem in obstetrics. Typically, aggressive antihypertensive drug treatment options are avoided to prevent pharmacological-induced hypotension. Another major concern of administering antihypertensive drugs during pregnancy is possible adverse fetal outcome. In addition, management of hypertension during pregnancy in chronic hypertensive patients or in patients with prior kidney problems are carefully considered. Recent studies suggest that PE patients are at increased cardiovascular risk postpartum. Therefore, these patients need to be monitored postpartum for the subsequent development of other cardiovascular diseases. In this review article, we review the antihypertensive drugs currently being used to treat patients with PE and the advantages or disadvantages of using these drugs during pregnancy.

Citing Articles

Circulating microRNAs in Body Fluid: "Fingerprint" RNA Snippets Deeply Impact Reproductive Biology.

Mukherjee A, Verma A, Das T, Ghosh B, Ghosh Z Reprod Sci. 2024; 32(3):555-574.

PMID: 39658771 DOI: 10.1007/s43032-024-01753-y.

Diagnosis and Treatment of Eclampsia.

Katsi V, Svigkou A, Dima I, Tsioufis K J Cardiovasc Dev Dis. 2024; 11(9).

PMID: 39330315 PMC: 11432638. DOI: 10.3390/jcdd11090257.

The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis.

Wang Y, Ssengonzi R, Townley-Tilson W, Kayashima Y, Maeda-Smithies N, Li F Int J Mol Sci. 2024; 25(16).

PMID: 39201703 PMC: 11354233. DOI: 10.3390/ijms25169017.

Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies.

Schofield L, Endacott S, Delforce S, Lumbers E, Pringle K Curr Hypertens Rep. 2024; 26(12):483-495.

PMID: 39093387 PMC: 11455731. DOI: 10.1007/s11906-024-01316-1.

Advancing hypertensive disorders of pregnancy management: insights from the 5th preeclampsia scientific symposium in Ghana.

Koi-Larbi K, Obiri D, Browne J, Fondjo L, Katsande S, Garti I BMC Proc. 2024; 18(Suppl 10):12.

PMID: 38867245 PMC: 11170767. DOI: 10.1186/s12919-024-00295-0.

References

Duley L, Henderson-Smart D . Magnesium sulphate versus phenytoin for eclampsia. Cochrane Database Syst Rev. 2003; (4):CD000128. DOI: 10.1002/14651858.CD000128. View

Duley L, Henderson-Smart D . Magnesium sulphate versus diazepam for eclampsia. Cochrane Database Syst Rev. 2003; (4):CD000127. DOI: 10.1002/14651858.CD000127. View

Rezaei Z, Sharbaf F, Pourmojieb M, Youefzadeh-Fard Y, Motevalian M, Khazaeipour Z . Comparison of the efficacy of nifedipine and hydralazine in hypertensive crisis in pregnancy. Acta Med Iran. 2011; 49(11):701-6. View

Lain K, Roberts J . Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 2002; 287(24):3183-6. DOI: 10.1001/jama.287.24.3183. View

Cunningham F, Lindheimer M . Hypertension in pregnancy. N Engl J Med. 1992; 326(14):927-32. DOI: 10.1056/NEJM199204023261405. View

Raheem I, Saaid R, Omar S, Tan P . Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy: a randomised trial. BJOG. 2011; 119(1):78-85. DOI: 10.1111/j.1471-0528.2011.03151.x. View

Duley L, Gulmezoglu A . Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database Syst Rev. 2001; (1):CD002960. DOI: 10.1002/14651858.CD002960. View

Shekhar S, Sharma C, Thakur S, Verma S . Oral nifedipine or intravenous labetalol for hypertensive emergency in pregnancy: a randomized controlled trial. Obstet Gynecol. 2013; 122(5):1057-1063. DOI: 10.1097/AOG.0b013e3182a9ea68. View

Magee L, Miremadi S, Li J, Cheng C, Ensom M, Carleton B . Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia. Am J Obstet Gynecol. 2005; 193(1):153-63. DOI: 10.1016/j.ajog.2004.11.059. View

10.

Li X, Guo P, Xue Y, Gou W, Tong M, Chen Q . An analysis of the differences between early and late preeclampsia with severe hypertension. Pregnancy Hypertens. 2016; 6(1):47-52. DOI: 10.1016/j.preghy.2015.12.003. View

11.

Magee L, von Dadelszen P, Singer J, Lee T, Rey E, Ross S . Do labetalol and methyldopa have different effects on pregnancy outcome? Analysis of data from the Control of Hypertension In Pregnancy Study (CHIPS) trial. BJOG. 2015; 123(7):1143-51. DOI: 10.1111/1471-0528.13569. View

12.

Molvi S, Mir S, Rana V, Jabeen F, Malik A . Role of antihypertensive therapy in mild to moderate pregnancy-induced hypertension: a prospective randomized study comparing labetalol with alpha methyldopa. Arch Gynecol Obstet. 2012; 285(6):1553-62. DOI: 10.1007/s00404-011-2205-2. View

13.

McDonald S, Han Z, Walsh M, Gerstein H, Devereaux P . Kidney disease after preeclampsia: a systematic review and meta-analysis. Am J Kidney Dis. 2010; 55(6):1026-39. DOI: 10.1053/j.ajkd.2009.12.036. View

14.

Dekker G . Risk factors for preeclampsia. Clin Obstet Gynecol. 1999; 42(3):422-35. DOI: 10.1097/00003081-199909000-00002. View

15.

Vikse B, Irgens L, Leivestad T, Skjaerven R, Iversen B . Preeclampsia and the risk of end-stage renal disease. N Engl J Med. 2008; 359(8):800-9. DOI: 10.1056/NEJMoa0706790. View

16.

Magee L, Cham C, Waterman E, Ohlsson A, von Dadelszen P . Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis. BMJ. 2003; 327(7421):955-60. PMC: 259162. DOI: 10.1136/bmj.327.7421.955. View

17.

Duley L, Meher S, Jones L . Drugs for treatment of very high blood pressure during pregnancy. Cochrane Database Syst Rev. 2013; (7):CD001449. PMC: 7073408. DOI: 10.1002/14651858.CD001449.pub3. View

18.

Mol B, Roberts C, Thangaratinam S, Magee L, de Groot C, Hofmeyr G . Pre-eclampsia. Lancet. 2015; 387(10022):999-1011. DOI: 10.1016/S0140-6736(15)00070-7. View

19.

Smith P, Anthony J, JOHANSON R . Nifedipine in pregnancy. BJOG. 2000; 107(3):299-307. DOI: 10.1111/j.1471-0528.2000.tb13222.x. View

20.

. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013; 122(5):1122-1131. DOI: 10.1097/01.AOG.0000437382.03963.88. View