Top-down Feedback Controls Spatial Summation and Response Amplitude in Primate Visual Cortex

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Jun 13

PMID 29892057

Citations 87

Authors

Lauri Nurminen

Sam Merlin

Maryam Bijanzadeh

Frederick Federer

Alessandra Angelucci

Affiliations

Soon will be listed here.

Abstract

Sensory information travels along feedforward connections through a hierarchy of cortical areas, which, in turn, send feedback connections to lower-order areas. Feedback has been implicated in attention, expectation, and sensory context, but the mechanisms underlying these diverse feedback functions are unknown. Using specific optogenetic inactivation of feedback connections from the secondary visual area (V2), we show how feedback affects neural responses in the primate primary visual cortex (V1). Reducing feedback activity increases V1 cells' receptive field (RF) size, decreases their responses to stimuli confined to the RF, and increases their responses to stimuli extending into the proximal surround, therefore reducing surround suppression. Moreover, stronger reduction of V2 feedback activity leads to progressive increase in RF size and decrease in response amplitude, an effect predicted by a recurrent network model. Our results indicate that feedback modulates RF size, surround suppression and response amplitude, similar to the modulatory effects of visual spatial attention.

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