Phoenixin-A Pleiotropic Gut-Brain Peptide

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Jun 13

PMID 29891773

Citations 12

Authors

Martha A Schalla

Andreas Stengel

Affiliations

Soon will be listed here.

Abstract

Phoenixin is a recently discovered brain peptide initially thought to be restricted to reproductive functions. The subsequent identification of phoenixin’s expression in peripheral tissues was accompanied by the description of several other actions of this hormone, such as effects on behavior, sensory perception, memory retention, the cardiovascular system as well as food intake, pointing towards a pleiotropic role of this peptide. The present review will discuss the present knowledge on phoenixin and the signaling involved as well as highlight gaps in knowledge to stimulate further research.

Citing Articles

Immunolocalization and quantification of the phoenixin and GPR173 in the gastrointestinal tract of Holstein-Friesian bulls.

Kras K, Osiak-Wicha C, Arciszewski M BMC Vet Res. 2025; 21(1):76.

PMID: 39966825 PMC: 11834677. DOI: 10.1186/s12917-025-04545-x.

Examining the Potential Applicability of Orexigenic and Anorexigenic Peptides in Veterinary Medicine for the Management of Obesity in Companion Animals.

Osiak-Wicha C, Kras K, Tomaszewska E, Muszynski S, Arciszewski M Curr Issues Mol Biol. 2024; 46(7):6725-6745.

PMID: 39057043 PMC: 11275339. DOI: 10.3390/cimb46070401.

Expression of Genes Encoding Selected Orexigenic and Anorexigenic Peptides and Their Receptors in the Organs of the Gastrointestinal Tract of Calves and Adult Domestic Cattle ().

Kras K, Ropka-Molik K, Muszynski S, Arciszewski M Int J Mol Sci. 2024; 25(1).

PMID: 38203717 PMC: 10779135. DOI: 10.3390/ijms25010533.

Phoenixin-14 as a novel direct regulator of porcine luteal cell functions†.

Mlyczynska E, Kurowska P, Wachowska D, Grzesiak M, Dupont J, Rak A Biol Reprod. 2023; 110(1):154-168.

PMID: 37815939 PMC: 10790343. DOI: 10.1093/biolre/ioad138.

Locked Out: Phoenixin-14 Does Not Cross a Stem-Cell-Derived Blood-Brain Barrier Model.

Schalla M, Oerter S, Cubukova A, Metzger M, Appelt-Menzel A, Stengel A Brain Sci. 2023; 13(7).

PMID: 37508911 PMC: 10377091. DOI: 10.3390/brainsci13070980.

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