Fluid Shear Stress and Tumor Metastasis

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2018 Jun 12

PMID 29888101

Citations 102

Authors

Qiong Huang

Xingbin Hu

Wanming He

Yang Zhao

Shihui Hao

Qijing Wu

Shaowei Li

Shuyi Zhang

Min Shi

Affiliations

Soon will be listed here.

Abstract

The tumor microenvironment (TME) is a key factor regulating tumor cell invasion and metastasis. The effects of biochemical factors such as stromal cells, immune cells, and cytokines have been previously investigated. Owing to restrictions by the natural barrier between physical and biochemical disciplines, the role of physical factors in tumorigenesis is unclear. However, with the emergence of interdisciplinary mechanobiology and continuous advancements therein in the past 30 years, studies on the effect of physical properties such as hardness or shear stress on tumorigenesis and tumor progression are constantly renewing our understanding of mechanotransduction mechanisms. Shear stress, induced by liquid flow, is known to actively participate in proliferation, apoptosis, invasion, and metastasis of tumor cells. The present review discusses the progress and achievements in studies on tumor fluid microenvironment in recent years, especially fluid shear stress, on tumor metastasis, and presents directions for future study.

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