The Causal Relationship Between Epigenetic Abnormality and Cancer Development: in Vivo Reprogramming and Its Future Application

Overview

Journal Proc Jpn Acad Ser B Phys Biol Sci

Specialties Biology
Science

Date 2018 Jun 12

PMID 29887568

Citations 7

Authors

Yosuke Yamada

Yasuhiro Yamada

Affiliations

Soon will be listed here.

Abstract

There is increasing evidence that cancer cells acquire epigenetic abnormalities as well as genetic mutations during cancer initiation, maintenance, and progression. However, the role of epigenetic regulation in cancer development, especially at the organismal level, remains to be elucidated. Here, we describe the causative role of epigenetic abnormalities in cancer, referring to our in vivo studies using induced pluripotent stem cell technology. We first summarize epigenetic reorganization during cellular reprogramming and introduce our in vivo reprogramming system for investigating the impact of dedifferentiation-driven epigenetic disruption in cancer development. Accordingly, we propose that particular types of cancer, in which causative mutations are not often detectable, such as pediatric cancers like Wilms' tumor, may develop mainly through alterations in epigenetic regulation triggered by dedifferentiation. Finally, we discuss issues that still remain to be resolved, and propose possible future applications of in vivo reprogramming to study cancer and other biological phenomena including organismal aging.

Citing Articles

Research of reprogramming toward clinical applications in regenerative medicine: A concise review.

Nakatsukasa Y, Yamada Y, Yamada Y Regen Ther. 2024; 28:12-19.

PMID: 39678397 PMC: 11638634. DOI: 10.1016/j.reth.2024.11.008.

Is Cancer Metabolism an Atavism?.

Fanchon E, Stephanou A Cancers (Basel). 2024; 16(13).

PMID: 39001477 PMC: 11240651. DOI: 10.3390/cancers16132415.

Epigenetic regulation in lung cancer.

Ramazi S, Dadzadi M, Daddzadi M, Sahafnejad Z, Allahverdi A MedComm (2020). 2023; 4(6):e401.

PMID: 37901797 PMC: 10600507. DOI: 10.1002/mco2.401.

Dedifferentiation and reprogramming of committed cells in wound repair (Review).

Guo Y, Wu W, Yang X, Fu X Mol Med Rep. 2022; 26(6).

PMID: 36321786 PMC: 9644423. DOI: 10.3892/mmr.2022.12886.

Correlations between histological characterizations and methylation statuses of tumour suppressor genes in Wilms' tumours.

Lai Y, Lu M, Wang W, Hou T, Kuo C Int J Exp Pathol. 2022; 103(3):121-128.

PMID: 35436013 PMC: 9107610. DOI: 10.1111/iep.12442.

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