Sacral Chordoma : A Review of Literature

Overview

Journal J Orthop

Specialty Orthopedics

Date 2018 Jun 9

PMID 29881220

Citations 25

Authors

S Pillai

S Govender

Affiliations

Soon will be listed here.

Abstract

Aim: To review the incidence and prevalence of sacral chordoma and the appropriate surgical management and formulate a criteria for early diagnosis.

Materials And Methods: Thirty eight articles on the subject of sacral chordoma and extrapolated data of clinical and surgical significance.

Results: The commonest presenting feature in patients with sacral chordoma was lower back pain which was worse on sitting and up to a third of these patients had associated urinary tract infections, constipation or symptoms of disc herniation. The hallmark of sacral chordoma is lower back pain with poor response to non-steroidal anti-inflammatory drugs.Disease free eradication in chordoma is rare and not without neurological deficit. The common sacral levels involved ie. S2,3 have to be sacrificed to achieve adequate margins4. Whilst wide excision via posterior surgery shows a decrease in recurrence, the overall survival still remains low.

Citing Articles

Exceptionally giant neglected sacral chordoma in a post-poliotic residual paralysis patient - a rare case scenario.

Kantiwal P, Aggarwal A, Yadav S, Gahlot N, Elhence A Am J Neurodegener Dis. 2024; 13(3):13-22.

PMID: 39308697 PMC: 11411203. DOI: 10.62347/EKNJ6411.

Spinal cord stimulation for chronic pain treatment following sacral chordoma resection: illustrative case.

Taghlabi K, Hassan T, Somawardana I, Rajendran S, Doomi A, Bhenderu L J Neurosurg Case Lessons. 2023; 6(26).

PMID: 38145561 PMC: 10751222. DOI: 10.3171/CASE23540.

Chordoma: A Comprehensive Systematic Review of Clinical Trials.

Chen S, Ulloa R, Soffer J, Alcazar-Felix R, Snyderman C, Gardner P Cancers (Basel). 2023; 15(24).

PMID: 38136345 PMC: 10741859. DOI: 10.3390/cancers15245800.

Linc01116 Silencing Inhibits the Proliferation and Invasion, Promotes Apoptosis of Chordoma Cells Regulating the Expression of Mir-9-5p/PKG1.

Liu J, Qi Y, Hou S, Zhang S, Wang Z Curr Mol Med. 2023; 24(8):1056-1071.

PMID: 37489776 DOI: 10.2174/1566524023666230719121758.

Sacrococcygeal chordoma-illustrative cases and our experience.

Yadav S, Kunal K, Kantiwal P, Rajnish R, Elhence A, Gupta S Int J Burns Trauma. 2023; 13(3):110-115.

PMID: 37455803 PMC: 10349324.

References

Housari G, Gonzalez M, Calero P, Beni R, Lobo E . Sacral chordoma: management of a rare disease in a tertiary hospital. Clin Transl Oncol. 2012; 15(4):327-30. DOI: 10.1007/s12094-012-0919-7. View

Varga P, Lazary A . Chordoma of the sacrum: "en bloc" high partial sacrectomy. Eur Spine J. 2010; 19(6):1037-8. PMC: 7571632. DOI: 10.1007/s00586-010-1459-x. View

McMaster M, Goldstein A, Bromley C, Ishibe N, Parry D . Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control. 2001; 12(1):1-11. DOI: 10.1023/a:1008947301735. View

Kaplan K, Spivak J, Bendo J . Embryology of the spine and associated congenital abnormalities. Spine J. 2005; 5(5):564-76. DOI: 10.1016/j.spinee.2004.10.044. View

Akiyama T, Yamamoto A, Kashima T, Ishida T, Shinoda Y, Goto T . Juxtacortical chondroma of the sacrum. J Orthop Sci. 2008; 13(5):476-80. DOI: 10.1007/s00776-008-1248-0. View

Asavamongkolkul A, Waikakul S . Wide resection of sacral chordoma via a posterior approach. Int Orthop. 2011; 36(3):607-12. PMC: 3291754. DOI: 10.1007/s00264-011-1381-9. View

Fourney D, Ziya L Gokaslan . Current management of sacral chordoma. Neurosurg Focus. 2004; 15(2):E9. DOI: 10.3171/foc.2003.15.2.9. View

Kishimoto R, Omatsu T, Hasegawa A, Imai R, Kandatsu S, Kamada T . Imaging characteristics of metastatic chordoma. Jpn J Radiol. 2012; 30(6):509-16. DOI: 10.1007/s11604-012-0086-3. View

Osaka S, Kodoh O, Sugita H, Osaka E, Yoshida Y, Ryu J . Clinical significance of a wide excision policy for sacrococcygeal chordoma. J Cancer Res Clin Oncol. 2005; 132(4):213-8. DOI: 10.1007/s00432-005-0067-3. View

10.

Chen Y, Liebsch N, Kobayashi W, Goldberg S, Kirsch D, Calkins G . Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas. Spine (Phila Pa 1976). 2013; 38(15):E930-6. DOI: 10.1097/BRS.0b013e318296e7d7. View

11.

Kayani B, Sewell M, Hanna S, Saifuddin A, Aston W, Pollock R . Prognostic factors in the operative management of dedifferentiated sacral chordomas. Neurosurgery. 2014; 75(3):269-75. DOI: 10.1227/NEU.0000000000000423. View

12.

Park L, DeLaney T, Liebsch N, Hornicek F, Goldberg S, Mankin H . Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys. 2006; 65(5):1514-21. DOI: 10.1016/j.ijrobp.2006.02.059. View

13.

Fourney D, Ziya L Gokaslan . Spinal instability and deformity due to neoplastic conditions. Neurosurg Focus. 2005; 14(1):e8. DOI: 10.3171/foc.2003.14.1.9. View

14.

Carey K, Bestic J, Attia S, Cortese C, Jain M . Diffuse skeletal muscle metastases from sacral chordoma. Skeletal Radiol. 2014; 43(7):985-9. DOI: 10.1007/s00256-013-1794-1. View

15.

Farsad K, Kattapuram S, Sacknoff R, Ono J, Nielsen G . Sacral chordoma. Radiographics. 2009; 29(5):1525-30. DOI: 10.1148/rg.295085215. View

16.

Atalar H, Selek H, Yildiz Y, Saglik Y . Management of sacrococcygeal chordomas. Int Orthop. 2006; 30(6):514-8. PMC: 3172743. DOI: 10.1007/s00264-006-0095-x. View

17.

Bergh P, Kindblom L, Gunterberg B, Remotti F, Ryd W, Meis-Kindblom J . Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer. 2000; 88(9):2122-34. DOI: 10.1002/(sici)1097-0142(20000501)88:9<2122::aid-cncr19>3.0.co;2-1. View

18.

Williams S, Beckerman B, Pina Fonti M . A 69-year-old presenting with musculoskeletal low back pain: a case of lumbosacral chordoma. J Chiropr Med. 2015; 13(2):144-8. PMC: 4322016. DOI: 10.1016/j.jcm.2014.06.007. View

19.

Hanna S, Aston W, Briggs T, Cannon S, Saifuddin A . Sacral chordoma: can local recurrence after sacrectomy be predicted?. Clin Orthop Relat Res. 2008; 466(9):2217-23. PMC: 2493011. DOI: 10.1007/s11999-008-0356-7. View

20.

Wang W, Abramson J, Ganguly A, Rosenberg A . The surgical pathology of notochordal remnants in adult intervertebral disks: a report of 3 cases. Am J Surg Pathol. 2008; 32(8):1123-9. DOI: 10.1097/PAS.0b013e3181757954. View