Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2018 Jun 8

PMID 29876539

Citations 4

Authors

Bodhisattwa Mondal

Hongxia Chen

Weihua Wen

Ercole L Cavalieri

Eleanor G Rogan

Muhammad Zahid

Affiliations

Soon will be listed here.

Abstract

Arsenic trioxide (AsO) is an environmental carcinogen and a putative endocrine disruptor. Resveratrol has been shown to reverse AsO-induced oxidative damage. In immortalized but nontransformed estrogen receptor α-negative human breast cells (MCF10A), we observed that 25 μM resveratrol ameliorated AsO-induced cytotoxicity. AsO, in the presence or absence of 25 μM resveratrol, induced quinone reductase (NAD(P)H quinone dehydrogenase 1), via the induction of NFE2-related factor 2. AsO caused a repression of cytochrome P450 (CYP)1B1, but the addition of 25 μM resveratrol rescued the expression of cytochrome P450 1B1 and kept it at a constant level. Therefore, 25 μM resveratrol can modulate the effects of AsO on enzymes involved in estrogen metabolism.

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